公开(公告)号：US08777874B2

公开(公告)日：2014-07-15

申请号：US13114838

申请日：2011-05-24

申请人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

发明人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

IPC分类号： A61B7/00

CPC分类号： A61B5/0823 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/686 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/3621 ,  A61N1/3627

摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.

摘要翻译： 本公开涉及使用声信号检测咳嗽和咳嗽发作。 在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。 在一些示例中，可植入医疗装置还执行咳嗽严重度评估。 在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

公开(公告)号：US20120302898A1

公开(公告)日：2012-11-29

申请号：US13114838

申请日：2011-05-24

申请人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

发明人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

IPC分类号： A61B5/0205 ,  A61N1/365 ,  A61B5/11

CPC分类号： A61B5/0823 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/686 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/3621 ,  A61N1/3627

摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.

摘要翻译： 本公开涉及使用声信号检测咳嗽和咳嗽发作。 在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。 在一些示例中，可植入医疗装置还执行咳嗽严重度评估。 在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

公开(公告)号：US08565898B2

公开(公告)日：2013-10-22

申请号：US11116621

申请日：2005-04-28

申请人： Vinod Sharma ,  Daniel C. Sigg

发明人： Vinod Sharma ,  Daniel C. Sigg

IPC分类号： A61N1/00 ,  A61K38/00 ,  A61K38/16

CPC分类号： A61N1/362 ,  A61K9/0019 ,  A61K31/221 ,  A61K38/177 ,  A61N1/0568

摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

公开(公告)号：US20110300107A1

公开(公告)日：2011-12-08

申请号：US13096135

申请日：2011-04-28

申请人： Vinod Sharma ,  Xiaohong Qiu

发明人： Vinod Sharma ,  Xiaohong Qiu

IPC分类号： A61K31/7088 ,  A61P9/00 ,  C12N5/10 ,  A61K35/00

CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N2750/14143

摘要： The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.

摘要翻译： 该方法可以包括向有需要的受试者施用有效量的HCN多核苷酸。 HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。 参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。

公开(公告)号：US20090034128A1

公开(公告)日：2009-02-05

申请号：US11897936

申请日：2007-08-31

申请人： Vinod Sharma ,  Hyung Jai Lee

发明人： Vinod Sharma ,  Hyung Jai Lee

IPC分类号： G11B21/24

CPC分类号： G11B5/4826 ,  G11B5/4873 ,  G11B5/5552

摘要： A hard disk drive using a micro-actuator assembly to position a slider over a track on a rotating disk surface. The micro-actuator assembly includes a first piezoelectric device and a second piezoelectric device, both mechanically coupled to the slider. The first piezoelectric device includes a first terminal electrically coupled to a first voltage line and a second terminal electrically coupled to a ground line. The second piezoelectric device includes a third terminal electrically coupled to a ground line and a fourth terminal electrically coupled to a voltage line. A voltage applied to the first voltage line stimulates only the first piezoelectric device to alter a lateral position of the slider over the rotating disk surface, and a second voltage applied to the second voltage line stimulates only the second piezoelectric device to alter the lateral position of the slider over the rotating disk surface.

摘要翻译： 使用微型致动器组件的硬盘驱动器将滑块定位在旋转盘表面上的轨道上。 微致动器组件包括机械地联接到滑块的第一压电装置和第二压电装置。 第一压电器件包括电耦合到第一电压线的第一端子和电耦合到接地线的第二端子。 第二压电器件包括电耦合到接地线的第三端子和电耦合到电压线的第四端子。 施加到第一电压线的电压仅刺激第一压电装置来改变滑块在旋转盘表面上的横向位置，并且施加到第二电压线的第二电压仅刺激第二压电装置改变第二压电装置的横向位置 滑块越过旋转盘表面。

公开(公告)号：US20080259480A1

公开(公告)日：2008-10-23

申请号：US11787879

申请日：2007-04-17

申请人： Hoa Pham ,  Vinod Sharma ,  Sang Lee

发明人： Hoa Pham ,  Vinod Sharma ,  Sang Lee

IPC分类号： G11B5/455 ,  G11B15/64 ,  G11B5/56

CPC分类号： G11B5/455 ,  G11B5/60 ,  G11B5/6064

摘要： A glide head that can be used to certify disks of hard disk drives. The glide head includes a heater that can change the temperature of a slider surface of the head and vary the head flying height. The slider surface may induce the negative pressure so that the glide head more accurately simulates a head used in a production disk drive. A piezoelectric transducer may be coupled to the glide head so that contact between the head and a disk may be sensed and recorded in a disk certification routine.

摘要翻译： 可用于认证硬盘驱动器磁盘的滑动头。 滑行头包括可以改变头部的滑块表面的温度并改变头部飞行高度的加热器。 滑块表面可以引起负压，使得滑动头更准确地模拟生产磁盘驱动器中使用的磁头。 压电传感器可以耦合到滑动头，使得头和盘之间的接触可以被感测并记录在磁盘认证程序中。

公开(公告)号：US20080002302A1

公开(公告)日：2008-01-03

申请号：US11435271

申请日：2006-05-15

申请人： Hae-sung Kwon ,  Eo-Jin Hong ,  Yun-Sik Han ,  Vinod Sharma ,  Hyung Lee

发明人： Hae-sung Kwon ,  Eo-Jin Hong ,  Yun-Sik Han ,  Vinod Sharma ,  Hyung Lee

IPC分类号： G11B5/48

CPC分类号： G11B5/4826 ,  G11B5/40 ,  G11B5/5582

摘要： This invention stems from knowing that a head gimbal assembly has twice as much of its mass centered on its base plate as it has on its slider performs better in terms of resilience to mechanical shock than one with twice as much mass on the slider as on its base plate. The inventors realized that while these two configurations in normal operation are almost identical, during the impulse and after shocks, the slider with the smaller ratio of mass to the base plate performs better. The invention includes manufacturing methods for the head gimbal assembly, the head stack assembly, and the hard disk drive, as well as these items as products of their respective manufacturing processes.

摘要翻译： 本发明源于知道头部万向节组件的质量是其基板的两倍，因为它的滑块在弹性回弹性方面比在滑块上具有两倍质量的弹性更好。 底盘。 发明人意识到，虽然这两种正常操作中的这两种配置几乎相同，但是在冲击和冲击之后，质量与基板之间的比例较小的滑块性能更好。 本发明包括头部万向节组件，磁头组合组件和硬盘驱动器的制造方法，以及作为其各自制造工艺的产品的这些项目。

公开(公告)号：US20070165323A1

公开(公告)日：2007-07-19

申请号：US11331487

申请日：2006-01-13

申请人： Haesung Kwon ,  Vinod Sharma ,  Hyung Lee

发明人： Haesung Kwon ,  Vinod Sharma ,  Hyung Lee

IPC分类号： G11B21/02 ,  G11B27/36

CPC分类号： G11B5/6005 ,  G11B5/40

摘要： Method estimating flying height of read-write head in slider near rotating disk surface. Sensing leakage current between slider and spindle motor to create potential difference measurement. Converting potential difference measurement to create estimate of flying height. Method controlling flying height using method for estimating by adjusting vertical actuation signal to micro-actuator assembly. Embodiments implement these methods. Embedded circuit and hard disk drive, each including the apparatus. The invention includes methods of manufacturing and their products.

公开(公告)号：US07190993B2

公开(公告)日：2007-03-13

申请号：US10701710

申请日：2003-11-04

申请人： Vinod Sharma ,  Zhou Xiaohong

发明人： Vinod Sharma ,  Zhou Xiaohong

IPC分类号： A61B5/04

CPC分类号： A61N1/056 ,  A61B5/042 ,  A61N1/371

摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

公开(公告)号：US20060247697A1

公开(公告)日：2006-11-02

申请号：US11116621

申请日：2005-04-28

申请人： Vinod Sharma ,  Daniel Sigg

发明人： Vinod Sharma ,  Daniel Sigg

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61K9/0019 ,  A61K31/221 ,  A61K38/177 ,  A61N1/0568

摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用试剂用于调制心脏传导系统中的节点，包括使用一个和一组K + SUPER通道或等同物的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。