公开(公告)号：US12054486B2

公开(公告)日：2024-08-06

申请号：US17951640

申请日：2022-09-23

申请人： Xenon Pharmaceuticals Inc.

发明人： Verner Alexander Lofstrand ,  Jung Yun Kim ,  Helen Clement ,  Kristen Nicole Burford ,  Paul Charifson ,  Shawn Johnstone ,  Juliette Sabbatani ,  Jan Felix Scholtes ,  Wei Zhang ,  Shaoyi Sun

IPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D491/052

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D491/052

摘要： The present disclosure is directed to compounds of formula (1):






wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20240101531A1

公开(公告)日：2024-03-28

申请号：US18330100

申请日：2023-06-06

申请人： Xenon Pharmaceuticals Inc.

发明人： Paul Scott Charifson ,  Christoph Martin Dehnhardt ,  Julien A. Delbrouck ,  Thilo Focken ,  Wei Gong ,  Shawn Johnstone ,  Xiangyu Li ,  Jia Yi Mo ,  Juliette Sabbatani ,  Hong Wang ,  Steven Sigmund Wesolowski ,  Alla Yurevna Zenova ,  Wei Zhang

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D495/04 ,  C07D513/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D413/14 ,  C07D487/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/00 ,  A61P25/08

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D495/04 ,  C07D513/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D413/14 ,  C07D487/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/002 ,  A61P25/08 ,  C07B2200/05

摘要： The present disclosure is directed to compounds of Formula (1):




wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20230203007A1

公开(公告)日：2023-06-29

申请号：US17951644

申请日：2022-09-23

申请人： Xenon Pharmaceuticals Inc.

发明人： Verner Alexander Lofstrand ,  Jung Yun Kim ,  Helen Clement ,  Kristen Nicole Burford ,  Paul Charifson ,  Shawn Johnstone ,  Juliette Sabbatani ,  Jan Felix Scholtes ,  Wei Zhang ,  Shaoyi Sun ,  Michael Clark ,  Steve Wesolowski ,  Ravi Munuganti ,  Ramkumar Rajamani

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D487/04 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D213/82 ,  C07D213/74 ,  C07D491/107 ,  C07D498/08 ,  C07D471/10 ,  C07D471/08 ,  C07D487/10 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04 ,  C07D471/14 ,  C07F7/08

CPC分类号： C07D401/14 ,  C07D213/74 ,  C07D213/82 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D471/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/08 ,  C07F7/0812

摘要： The present disclosure is directed to compounds of formula (I):





wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20230144095A1

公开(公告)日：2023-05-11

申请号：US17951640

申请日：2022-09-23

申请人： Xenon Pharmaceuticals Inc.

发明人： Verner Alexander Lofstrand ,  Jung Yun Kim ,  Helen Clement ,  Kristen Nicole Burford ,  Paul Charifson ,  Shawn Johnstone ,  Juliette Sabbatani ,  Jan Felix Scholtes ,  Wei Zhang ,  Shaoyi Sun

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D413/14 ,  C07D401/04 ,  C07D491/052 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D413/14 ,  C07D401/04 ,  C07D491/052 ,  C07D487/04

摘要： The present disclosure is directed to compounds of formula (1):




wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.