公开(公告)号：US10131950B2

公开(公告)日：2018-11-20

申请号：US15010491

申请日：2016-01-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US12195800B2

公开(公告)日：2025-01-14

申请号：US17112608

申请日：2020-12-04

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker ,  Mehdi Momen

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US20210095346A1

公开(公告)日：2021-04-01

申请号：US17112608

申请日：2020-12-04

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker ,  Mehdi Momen

IPC: C12Q1/6883

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US10858708B2

公开(公告)日：2020-12-08

申请号：US16194659

申请日：2018-11-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US20190071729A1

公开(公告)日：2019-03-07

申请号：US16194659

申请日：2018-11-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US20160222451A1

公开(公告)日：2016-08-04

申请号：US15010491

申请日：2016-01-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A01K67/02 ,  C12Q2600/118 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

Abstract translation: 描述了用于诊断狗中非接触性颅关节十字韧带破裂（CCLR）倾向的方法和试剂盒。 该方法包括从狗分离基因组DNA，然后分析来自步骤中的基因组DNA，以通过全基因组关联研究确定与所选CCLR表型相关的选定基因座中出现的单核苷酸多态性。