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公开(公告)号：US11851670B2
公开(公告)日：2023-12-26
申请号：US16438424
申请日：2019-06-11
IPC分类号： C12N5/074 , C12N15/86 , G01N33/50 , A01K67/027 , C07K14/47 , C12N15/85 , C12N5/0735 , C12N15/79
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0696 , G01N33/5008 , C12N5/0606 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
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2.发明申请NUCLEIC ACID CONSTRUCTS ENCODING REPROGRAMMING FACTORS LINKED BY SELF-CLEAVING PEPTIDES 审中-公开编码由自清除肽连接的重组因子的核酸构建体公开(公告)号：US20170067081A1
公开(公告)日：2017-03-09
申请号：US15354604
申请日：2016-11-17
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0606 , C12N5/0696 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203 , G01N33/5008
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较不分化的状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。
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3.发明申请公开(公告)号：US20200032292A1
公开(公告)日：2020-01-30
申请号：US16438424
申请日：2019-06-11
IPC分类号： C12N15/86 , C12N5/074 , G01N33/50 , A01K67/027 , C07K14/47
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
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