- 专利标题： NUCLEIC ACID CONSTRUCTS ENCODING REPROGRAMMING FACTORS LINKED BY SELF-CLEAVING PEPTIDES
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申请号： US16438424申请日： 2019-06-11
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公开(公告)号： US20200032292A1公开(公告)日： 2020-01-30
- 发明人: Rudolf Jaenisch , Bryce Woodbury Carey
- 申请人： Whitehead Institute for Biomedical Research
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N5/074 ; G01N33/50 ; A01K67/027 ; C07K14/47
摘要：
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
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