公开(公告)号：US20220143220A1

公开(公告)日：2022-05-12

申请号：US17451428

申请日：2021-10-19

申请人： Washington University

发明人： Kyunghee Choi ,  Ashraf Ul Kabir ,  Karen Krchma

IPC分类号： A61K48/00 ,  A61P35/00 ,  C12N15/113

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods for modulating MYCT1. An aspect of the present disclosure provides for a method of regulating tumor angiogenesis (anti-angiogenesis, Myct1-targeted vascular control) and/or immunostimulation, which inhibit tumor growth, in a subject. The present disclosure provides methods to quantify MYCT1 to predict responsiveness of a subject having a cancer or tumor to a treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.

公开(公告)号：US20240325493A1

公开(公告)日：2024-10-03

申请号：US18623995

申请日：2024-04-01

申请人： Washington University

发明人： Kyunghee Choi ,  Karen Krchma ,  Ashraf Ul Kabir

IPC分类号： A61K38/18 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  C12Q1/6886

CPC分类号： A61K38/18 ,  A61K39/39558 ,  A61P35/00 ,  C12Q1/6886 ,  A61K48/00 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Among the various aspects of the present disclosure is the provision of a regulator of tumor cell functions and uses thereof. Methods to treat a cancer patient with immunotherapy and a Zbtb46 modulation agent are disclosed. A method to identify a cancer patient in need of an adjuvant therapy to an immunotherapy is also disclosed.