公开(公告)号：US10466249B2

公开(公告)日：2019-11-05

申请号：US15974923

申请日：2018-05-09

申请人： Warp Drive Bio, Inc.

发明人： Gregory L. Verdine ,  M. James Nichols ,  Sharon A. Townson ,  Uddhav Kumar Shigdel ,  Seung-Joo Lee ,  Dylan T. Stiles ,  Neville J. Anthony

IPC分类号： G01N33/68 ,  C07K1/08 ,  C07K5/083 ,  C07K7/64 ,  C07K1/13 ,  C07K5/02 ,  C12Q1/533 ,  G01N33/566 ,  C07K5/062

摘要： The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

公开(公告)号：US09989535B2

公开(公告)日：2018-06-05

申请号：US15282430

申请日：2016-09-30

申请人： Warp Drive Bio, Inc.

发明人： Gregory L. Verdine ,  M. James Nichols ,  Sharon A. Townson ,  Uddhav Kumar Shigdel ,  Seung-Joo Lee ,  Dylan T. Stiles ,  Neville J. Anthony

IPC分类号： G01N33/68 ,  C07K1/08 ,  C07K5/083 ,  C07K7/64 ,  C07K1/13 ,  C07K5/02 ,  C12Q1/533 ,  G01N33/566 ,  C07K5/062

CPC分类号： G01N33/6845 ,  C07K1/086 ,  C07K1/13 ,  C07K5/0215 ,  C07K5/06034 ,  C07K5/0808 ,  C07K7/64 ,  C07K7/645 ,  C12Q1/533 ,  G01N33/566 ,  G01N2333/82 ,  G01N2333/90209 ,  G01N2410/08 ,  G01N2500/02

摘要： The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.