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公开(公告)号：US10391095B2
公开(公告)日：2019-08-27
申请号：US16042206
申请日：2018-07-23
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US08987454B2
公开(公告)日：2015-03-24
申请号：US14182517
申请日：2014-02-18
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC: C07D471/02 , C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US11008305B2
公开(公告)日：2021-05-18
申请号：US16538992
申请日：2019-08-13
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: C07D401/14 , A61K41/00 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , C07D239/42 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/506 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53 , C07D401/12 , C07D403/12 , C07D403/14 , C07D403/04 , C07D413/04
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20160250212A1
公开(公告)日：2016-09-01
申请号：US15056137
申请日：2016-02-29
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: A61K31/506 , A61K9/20 , A61K31/5377 , A61K9/48
CPC classification number: A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20150111871A1
公开(公告)日：2015-04-23
申请号：US14515793
申请日：2014-10-16
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: C07D239/42 , C07D471/04 , C07D413/10 , C07D405/14 , A61K41/00 , C07D417/10 , C07D413/14 , C07D495/04 , C07D491/048 , C07D491/056 , C07D401/04 , C07D409/14
CPC classification number: A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作DNA-PK抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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Patent Agency Ranking
公开(公告)号：US20140194444A1
公开(公告)日：2014-07-10
申请号：US14155624
申请日：2014-01-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Juan-Miguel Jimenez , Andrew Miller , Jeremy Green , Huai Gao , Gregory Henkel , Michael Liu , Timothy Neuberger
IPC: C07D471/04 , C07D405/14
CPC classification number: C07D471/04 , C07D403/12 , C07D405/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130245273A1
公开(公告)日：2013-09-19
申请号：US13785019
申请日：2013-03-05
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Gregory Henkel , Michael Liu , Timothy Neuberger
IPC: C07D417/12
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4439 , A61K45/06 , C07D417/12
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20180208579A1
公开(公告)日：2018-07-26
申请号：US15860304
申请日：2018-01-02
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: C07D401/14 , C07D417/04 , C07D495/04 , C07D403/10 , C07D239/42 , C07D401/12 , C07D521/00 , C07D413/14 , C07D417/14 , C07D491/048 , C07D405/14 , C07D413/04 , C07D403/12 , C07D471/04 , C07D409/04 , C07D413/10 , C07D403/14 , C07D403/04 , C07D491/056 , C07D409/14 , C07D401/04
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180193341A1
公开(公告)日：2018-07-12
申请号：US15912074
申请日：2018-03-05
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: A61K31/506 , C07D521/00 , A61K47/54 , C07D491/056 , C07D491/048 , C07D471/04 , C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/04 , C07D239/42 , A61K41/00 , A61K31/5377 , A61K31/53 , A61K9/48 , A61K9/20 , C07D495/04
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09878993B2
公开(公告)日：2018-01-30
申请号：US15159378
申请日：2016-05-19
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC: C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D491/048 , C07D401/12 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D491/056 , C07D495/04 , C07D521/00
CPC classification number: C07D401/14 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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