公开(公告)号：US20230332107A1

公开(公告)日：2023-10-19

申请号：US18162129

申请日：2023-01-31

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Felicia PAGLIUCA ,  George HARB ,  Jason GAGLIA ,  Andrea VERGANI ,  Christopher THANOS

IPC: C12N5/071

CPC classification number: C12N5/0678 ,  C12N2501/15 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/02

Abstract: Disclosed herein are compositions, kits, and methods related to cell therapy for a disease characterized by high blood glucose levels over a long period of time, such as diabetes. In some aspects, the methods provided herein relate to administration of non-native pancreatic cells to subject with a disease characterized by high blood glucose levels over a long period of time, such as diabetes. In some aspects, the disclosure provides pharmaceutical compositions including non-native cells.