公开(公告)号：US20140141491A1

公开(公告)日：2014-05-22

申请号：US13967157

申请日：2013-08-14

申请人： Verenium Corporation

发明人： David P. WEINER ,  Ellen G. BURKE ,  Peter LUGINBUHL ,  Analia BUENO ,  Joslin M. CUENCA ,  Mervyn L. DE SOUZA ,  Sherry KOLLMANN

IPC分类号： C12N9/90

CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids.

摘要翻译： 本发明一般涉及酶，编码具有异构酶活性的酶的多核苷酸，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化分子内原子重新排列 催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋催化底物对映异构体的相互转化，催化仅具有一个中心的底物中不对称碳原子周围的立体化学反应 的不对称性，催化具有多于一个不对称中心的底物中不对称碳原子周围构型的立体化学反转，和/或催化氨基酸的外消旋化。