公开(公告)号：US11519859B2

公开(公告)日：2022-12-06

申请号：US16379100

申请日：2019-04-09

申请人： Vanderbilt University

发明人： Charles David Weaver ,  Brendan F. Dutter ,  Gary A. Sulikowski

IPC分类号： G01N21/64 ,  G01N33/68 ,  C07D493/10 ,  C09B11/24 ,  G01N33/84

摘要： Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl+ flux assays. The fluorescent thallium ion sensor compounds have a rhodol fluorophore attached to an amino dicarboxylic acid metal binding moiety. The compounds are prepared in the “pro-dye” form, with the rhodol oxygen and the carboxylic acids of the metal binding unit masked by protecting groups. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.

公开(公告)号：US20190308991A1

公开(公告)日：2019-10-10

申请号：US16379100

申请日：2019-04-09

申请人： Vanderbilt University

发明人： Charles David Weaver ,  Brendan F. Dutter ,  Gary A. Sulikowski

IPC分类号： C07D493/10 ,  G01N21/64 ,  G01N33/68

摘要： Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl+ flux assays. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.