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公开(公告)号：US20180085475A1
公开(公告)日：2018-03-29
申请号：US15567355
申请日：2016-05-02
IPC分类号： A61K49/00 , C09B62/343 , C09B62/78 , C09K11/06 , A61K31/454 , A61K31/517 , A61K31/58 , A61P27/02 , A61P43/00
摘要： A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
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公开(公告)号：US20160151517A1
公开(公告)日：2016-06-02
申请号：US14871866
申请日：2015-09-30
IPC分类号： A61K49/00 , G01N33/569 , G01N33/58 , C07D493/10
CPC分类号： A61K49/0052 , A61K49/0041 , A61K49/0043 , C07D493/10 , G01N33/533 , G01N33/582 , G01N2800/52 , G01N2800/7038
摘要： Exemplary probes for detecting hypoxic cells and tissue have the structure of
摘要翻译： 用于检测缺氧细胞和组织的示例性探针具有以下结构
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公开(公告)号：US10695446B2
公开(公告)日：2020-06-30
申请号：US15567355
申请日：2016-05-02
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , A61K31/4545 , A61K31/05 , A61K31/19 , A61K31/4178 , C07D493/16 , C07D403/14 , A61K31/4375 , A61K31/045 , C07D405/14 , G01N33/50 , C07D487/22 , A61K45/06 , C12Q1/26 , G01N33/52 , A61P27/02 , A61P43/00 , A61K31/454 , A61K31/517 , A61K31/58 , C09B62/343 , C09B62/78 , C09K11/06
摘要： A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
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公开(公告)号：US10076578B2
公开(公告)日：2018-09-18
申请号：US14871866
申请日：2015-09-30
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , C07D493/10 , G01N33/58 , G01N33/533
CPC分类号： A61K49/0052 , A61K49/0041 , A61K49/0043 , C07D493/10 , G01N33/533 , G01N33/582 , G01N2800/52 , G01N2800/7038
摘要： Exemplary probes for detecting hypoxic cells and tissue have the structure of
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