公开(公告)号：US20170362132A1

公开(公告)日：2017-12-21

申请号：US15692389

申请日：2017-08-31

Applicant: VITO NV

Inventor： Steven Hans Rik Wouter Mullens ,  lvo Thijs ,  Jan Roger Luyten ,  Wim Louis Bouwen

IPC: C04B35/626 ,  C04B35/622 ,  B82Y30/00 ,  B22F3/11 ,  C04B35/634

CPC classification number: C04B35/6263 ,  B22F3/1121 ,  B22F2998/00 ,  B82Y30/00 ,  C04B35/62231 ,  C04B35/62236 ,  C04B35/62245 ,  C04B35/6225 ,  C04B35/62259 ,  C04B35/62268 ,  C04B35/62281 ,  C04B35/62295 ,  C04B35/6266 ,  C04B35/634 ,  C04B2235/5252 ,  C04B2235/5264 ,  C04B2235/5284 ,  C04B2235/6021 ,  C04B2235/6026 ,  C04B2235/656 ,  C04B2235/6562 ,  C04B2235/6565 ,  C04B2235/6567 ,  C04B2235/661 ,  Y10T428/24355 ,  Y10T428/24802 ,  B22F3/227

Abstract: The present invention relates to a method for producing a three-dimensional macroporous filament construct having interconnected microporous filaments showing a suitable surface roughness and microporosity. The method includes the steps of: a) preparing a suspension having particles of a predetermined material, a liquid solvent, one or more binders and optionally one or more dispersants, b) depositing the suspension in the form of filaments in a predetermined three-dimensional pattern, preferably in a non-solvent environment, thereby creating a three-dimensional filament-based porous structure, c) inducing phase inversion, whereby said filaments are transformed from a liquid to a solid state, by exposing the filaments during the deposition of the filaments with a non-solvent vapour and to a liquid non-solvent, d) thermally treating the structure of step d) by calcining and sintering the structure. The invention further provides a three-dimensional macroporous filament construct having interconnected microporous filaments showing a specific surface roughness and microporosity. The invention also relates to various uses of the construct, including its use for the manufacture of a biomedical product, such as a synthetic bone implant or bone graft.