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公开(公告)号：US20210214345A1
公开(公告)日：2021-07-15
申请号：US17263272
申请日：2019-08-07
发明人： Makonen BELEMA , Manoj PATEL
IPC分类号： C07D403/14 , A61K31/513
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US20220389007A1
公开(公告)日：2022-12-08
申请号：US17763133
申请日：2020-09-29
发明人： Michael S. BOWSHER , Eric P. GILLIS , Christiana IWUAGWU , B Narasimhulu NAIDU , Kyle E. PARCELLA , Manoj PATEL
IPC分类号： C07D471/04 , C07D277/08 , A61P31/18
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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3.发明申请公开(公告)号：US20180162831A1
公开(公告)日：2018-06-14
申请号：US15579977
申请日：2016-07-06
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61P31/18
CPC分类号： C07D401/04 , A61P31/18 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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4.发明申请公开(公告)号：US20210024503A1
公开(公告)日：2021-01-28
申请号：US17042413
申请日：2019-04-11
发明人： Makonen BELEMA , John A. BENDER , David B. FRENNESSON , Eric P. GILLIS , Christiana IWUAGWU , John F. KADOW , B. Narasimhulu NAIDU , Kyle E. PARCELLA , Kevin M. PEESE , Ramkumar RAJAMANI , Mark G. SAULNIER , Alan Xiangdong WANG , Manoj PATEL , Michael S. BOWSHER
IPC分类号： C07D403/14 , A61P31/18 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/052
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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5.发明申请公开(公告)号：US20180147196A1
公开(公告)日：2018-05-31
申请号：US15580742
申请日：2016-07-07
发明人： Kyle J. EASTMAN , John F. KADOW , B. Narasimhulu NAIDU , Kyle E. PARCELLA , Manoj PATEL , Yong TU
IPC分类号： A61K31/4545 , C07D401/04 , C07D401/14 , A61K31/5365 , A61P31/18
CPC分类号： A61K31/4545 , A61K31/5365 , A61P31/18 , C07D401/04 , C07D401/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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6.发明申请PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 有权作为人免疫缺陷病毒复制的抑制剂的吡唑并嘧啶大环化合物公开(公告)号：US20170057977A1
公开(公告)日：2017-03-02
申请号：US15119431
申请日：2015-02-13
发明人： John F. KADOW , B. Narasimhulu NAIDU , Manoj PATEL , Kevin PEESE , Tao WANG , Zhiwei YIN , Zhongxing ZHANG
IPC分类号： C07D498/16 , A61K31/519 , C07D498/22 , A61K45/06
CPC分类号： C07D498/16 , A61K31/519 , A61K45/06 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
摘要翻译： 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV整合酶的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US20220211704A1
公开(公告)日：2022-07-07
申请号：US17603634
申请日：2020-04-27
发明人： Manoj PATEL
IPC分类号： A61K31/517 , A61K31/5365 , A61K31/537 , A61K31/506 , A61K31/675 , A61K31/4985 , A61K31/439 , A61K31/505 , A61K31/635 , A61K31/4439 , C07D403/14 , A61P31/18
摘要： The compounds depicted below, and pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US20210393633A1
公开(公告)日：2021-12-23
申请号：US17284855
申请日：2019-10-22
IPC分类号： A61K31/517 , A61K45/06 , C07D403/14 , C07D405/14 , C07D401/14 , A61K31/5377 , A61P31/18
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US20210379071A1
公开(公告)日：2021-12-09
申请号：US17288085
申请日：2019-11-04
发明人： Michael S. BOWSHER , Eric P. GILLIS , Christiana IWUAGWU , B. Narasimhulu NAIDU , Kyle E. PARCELLA , Manoj PATEL , Kevin M. PEESE
IPC分类号： A61K31/517 , A61K45/06 , C07D403/14 , C07D471/04 , A61P31/18 , A61K31/519
摘要： Compounds and pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth.
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10.发明申请公开(公告)号：US20190127351A1
公开(公告)日：2019-05-02
申请号：US16094536
申请日：2017-05-09
发明人： John F. KADOW , B. Narasimhulu NAIDU , Manoj PATEL , Michael A. WALKER , Tao WANG , Zhiwei YIN , Zhongxing ZHANG , Zhizhen Barbara ZHENG
IPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , A61K31/5365 , A61K31/4725 , A61K31/4709 , A61K31/4545 , C07D409/14 , C07D413/14 , C07D411/14 , A61P31/18
CPC分类号： C07D401/14 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5365 , A61P31/18 , C07D401/04 , C07D405/14 , C07D407/14 , C07D409/14 , C07D411/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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