-
1.发明授权Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages 有权抗巨噬细胞甘露糖受体单变量结构域用于肿瘤相关巨噬细胞的靶向和体内成像公开(公告)号：US09556273B2
公开(公告)日：2017-01-31
申请号：US14402301
申请日：2013-03-15
发明人： Jo Van Ginderachter , Patrick De Baetselier , Nick Devoogdt , Tony Lahoutte , Damya Laoui , Kiavash Movahedi , Geert Raes , Steve Schoonooghe
CPC分类号： C07K16/2851 , A61K47/48484 , A61K47/48561 , A61K47/48761 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K51/1027 , A61K51/1096 , B82Y5/00 , C07K2317/22 , C07K2317/35 , C07K2317/569
摘要： The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
摘要翻译： 本公开涉及针对人巨噬细胞甘露糖受体（MMR）的免疫球蛋白单可变结构域及其在肿瘤学领域的用途。 更具体地说，它涉及针对人MMR的免疫球蛋白单可变结构域，包括单域抗体（sdAb），以及它们在肿瘤相关巨噬细胞的靶向和体内成像中的应用，在癌症诊断和治疗领域的应用和监测 这种病。
-
公开(公告)号：US09617339B2
公开(公告)日：2017-04-11
申请号：US14775510
申请日：2014-03-17
发明人： Patrick De Baetselier , Geert Raes , Steve Schoonooghe , Jens De Vos , Tony Lahoutte , Nick Devoogdt , Sophie Hernot , Gezim Bala , Simon Tierens
IPC分类号： A61B5/00 , A61K39/395 , A61K51/10 , A61P9/10 , C07K16/28 , A61K49/04 , C07K14/705
CPC分类号： C07K16/2851 , A61B5/0033 , A61B5/0044 , A61B5/0073 , A61K39/3955 , A61K49/04 , A61K51/1027 , A61K51/1096 , C07K14/70596 , C07K16/2896 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
-
3.发明申请ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR USE IN CARDIOVASCULAR DISEASES 有权抗巨噬神经受体单克隆抗体用于心血管疾病的单一变异域公开(公告)号：US20160024213A1
公开(公告)日：2016-01-28
申请号：US14775510
申请日：2014-03-17
发明人： Patrick De Baetselier , Geert Raes , Steve Schoonooghe , Jens De Vos , Tony Lahoutte , Nick Devoogdt , Sophie Hernot , Gezim Bala , Simon Tierens
CPC分类号： C07K16/2851 , A61B5/0033 , A61B5/0044 , A61B5/0073 , A61K39/3955 , A61K49/04 , A61K51/1027 , A61K51/1096 , C07K14/70596 , C07K16/2896 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
摘要翻译： 本公开涉及心血管疾病领域。 特别地，提供了针对巨噬细胞甘露糖受体（MMR）的免疫球蛋白单可变结构域，其可用于诊断，预后和/或监测心血管疾病或作为治疗剂。 此外，本公开的抗巨噬细胞甘露糖受体（MMR）免疫球蛋白单可变结构域可用于心血管疾病的不同阶段，包括梗死后心血管事件。 此外，本公开的抗巨噬细胞甘露糖受体（MMR）免疫球蛋白单可变结构域特别可用于易受损的动脉粥样硬化斑块的体内靶向和/或成像。
-
公开(公告)号：US09913920B2
公开(公告)日：2018-03-13
申请号：US14820368
申请日：2015-08-06
发明人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
CPC分类号： A61K51/1027 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K49/0002 , B82Y5/00 , C07K16/2851 , C07K2317/22 , C07K2317/35
摘要： The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
-
公开(公告)号：US20150335770A1
公开(公告)日：2015-11-26
申请号：US14820368
申请日：2015-08-06
发明人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
CPC分类号： A61K51/1027 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K49/0002 , B82Y5/00 , C07K16/2851 , C07K2317/22 , C07K2317/35
摘要： The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
摘要翻译： 本公开涉及肿瘤相关巨噬细胞（TAM）的活动和特征。 特别地，针对TAM的标记提供免疫球蛋白单可变结构域，以及使用其免疫球蛋白单可变结构域用于肿瘤细胞的体内成像以及癌症诊断和治疗。
-
6.发明申请ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES 有权抗巨噬细胞受体单个变量域用于靶向和肿瘤相关巨噬细胞成像公开(公告)号：US20150093336A1
公开(公告)日：2015-04-02
申请号：US14402301
申请日：2013-03-15
发明人： Jo Van Ginderachter , Patrick De Baetselier , Nick Devoogdt , Tony Lahoutte , Damya Laoui , Kiavash Movahedi , Geert Raes , Steve Schoonooghe
CPC分类号： C07K16/2851 , A61K47/48484 , A61K47/48561 , A61K47/48761 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K51/1027 , A61K51/1096 , B82Y5/00 , C07K2317/22 , C07K2317/35 , C07K2317/569
摘要： The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
摘要翻译： 本公开涉及针对人巨噬细胞甘露糖受体（MMR）的免疫球蛋白单可变结构域及其在肿瘤学领域的用途。 更具体地说，它涉及针对人MMR的免疫球蛋白单可变结构域，包括单域抗体（sdAb），以及它们在肿瘤相关巨噬细胞的靶向和体内成像中的应用，在癌症诊断和治疗领域的应用和监测 这种病。
-
公开(公告)号：US20240067722A1
公开(公告)日：2024-02-29
申请号：US18269380
申请日：2021-12-20
发明人： Karine Breckpot , Katrijn Broos , Nick Devoogdt , Quentin Lecocq , Marleen Keyaerts , Geert Raes
CPC分类号： C07K16/2803 , A61P35/00 , A61K2039/505 , C07K2317/569 , C07K2317/76
摘要： The present disclosure relates to field of immune checkpoints in onco-immunology and their identification as potential targets for the treatment of cancer patients: it provides VHHs (Single-domain antibody fragments, also known as ‘heavy-chain variable domains’ or ‘nanobodies’) to detect and quantify in a non-invasive way the immune checkpoint LAG-3.
-
公开(公告)号：US11298433B2
公开(公告)日：2022-04-12
申请号：US15742161
申请日：2016-07-15
摘要： Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (VHH), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the VHH, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.
-
公开(公告)号：US20180036442A1
公开(公告)日：2018-02-08
申请号：US15329860
申请日：2015-07-29
发明人： Tony Lahoutte , Nick Devoogdt , Marleen Keyaerts
IPC分类号： A61K51/10 , C07K16/32 , C07K16/30 , G01N33/574
CPC分类号： A61K51/1051 , A61K51/1045 , A61K51/1069 , A61K51/1072 , A61K51/1078 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/57415 , G01N33/5748 , G01N2333/82
摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (VHH) or a functional fragment thereof, wherein said VHH or a functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions, that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for detection, imaging, prognosis and diagnosis of cancer as well as for predicting patient response(s) to therapeutics.
-
公开(公告)号：US20210147546A1
公开(公告)日：2021-05-20
申请号：US16977145
申请日：2019-03-01
发明人： Jo Van Ginderachter , Geert Raes , Nick Devoogdt , Marleen Keyaerts , Quentin Lecocq , Catarina Xavier , Karine Breckpot , Katrijn Broos , Jessica Bridoux
摘要： The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.025 秒)
