公开(公告)号：US20190016671A1

公开(公告)日：2019-01-17

申请号：US16032799

申请日：2018-07-11

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Nadia AHMAD ,  Corey ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Iuliana Luci ASGIAN ,  Joanne Louise CAMP ,  Lev Tyler Dewey FANNING ,  Sara Sabina HADIDA RUAH ,  Dennis HURLEY ,  Yvonne SCHMIDT ,  David SHAW ,  Urvi Jagdishbhai SHETH ,  Stephen Andrew THOMSON

IPC: C07C235/64 ,  C07D213/81 ,  C07D213/89 ,  C07D239/34 ,  C07D317/46 ,  C07D405/12 ,  C07D213/69 ,  C07D213/82 ,  C07D307/79

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20170145011A1

公开(公告)日：2017-05-25

申请号：US15369029

申请日：2016-12-05

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Sara Sabina HADIDA RUAH ,  Edward Adam KALLEL ,  Mark Thomas MILLER ,  Vijayalaksmi ARUMUGAM ,  Jason McCARTNEY ,  Corey ANDERSON ,  Peter Diederik Jan GROOTENHUIS ,  Licong JIANG

IPC: C07D471/20 ,  A61K31/499

CPC classification number: C07D471/20 ,  A61K31/499 ,  A61K31/506 ,  C07D519/00

Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：US20150174127A1

公开(公告)日：2015-06-25

申请号：US14578628

申请日：2014-12-22

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Sara Sabina HADIDA RUAH ,  Edward Adam KALLEL ,  Mark Thomas MILLER ,  Vijayalaksmi ARUMUGAM ,  Jason McCARTNEY ,  Corey ANDERSON ,  Peter Diederik Jan GROOTENHUIS ,  Licong JIANG

IPC: A61K31/499 ,  A61K31/506

CPC classification number: C07D471/20 ,  A61K31/499 ,  A61K31/506 ,  C07D519/00

Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的吡咯并吡嗪 - 螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：US20230286907A1

公开(公告)日：2023-09-14

申请号：US18065208

申请日：2022-12-13

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Nadia M. AHMAD ,  Corey ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Iuliana Luci ASGIAN ,  Joanne Louise CAMP ,  Lev Tyler Dewey FANNING ,  Sara Sabina HADIDA RUAH ,  Dennis HURLEY ,  Yvonne SCHMIDT ,  David SHAW ,  Urvi PATEL ,  Stephen Andrew THOMSON ,  Lidio Marx CARVALHO MEIRELES

IPC: C07C235/64 ,  A61K31/165 ,  C07D307/86 ,  C07C237/42 ,  C07D239/42 ,  C07D213/69 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D239/34 ,  C07D307/79 ,  C07D317/46 ,  C07D405/12

CPC classification number: C07C235/64 ,  A61K31/165 ,  C07D307/86 ,  C07C237/42 ,  C07D239/42 ,  C07D213/69 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D239/34 ,  C07D307/79 ,  C07D317/46 ,  C07D405/12 ,  C07B2200/05 ,  C07C2601/02

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20160159815A1

公开(公告)日：2016-06-09

申请号：US14903475

申请日：2014-07-08

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Michael Paul DENINNO ,  Corey ANDERSON ,  Erica Lynn CONROY ,  Bryan A. FRIEMAN ,  Peter Drederik Jan GROOTENHUIS ,  Sara Sabina HADIDA-RUAH ,  Dennis James HURLEY ,  Fabrice Jean Denis PIERRE ,  Alina SILINA ,  Johnny UY ,  Jinglan ZHOU

IPC: C07D491/056 ,  C07D221/04 ,  C07D491/048 ,  C07D405/06 ,  C07D405/12 ,  C07D487/04 ,  C07D401/06 ,  C07D491/044

CPC classification number: C07D491/056 ,  C07D221/04 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048

Abstract: The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及用作治疗疼痛的离子通道抑制剂的稠合哌啶酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：US20160152561A1

公开(公告)日：2016-06-02

申请号：US14906089

申请日：2014-07-18

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Sara Sabina HADIDA-RUAH ,  Corey ANDERSON ,  Andreas P. TERMIN ,  Brian Richard BEAR ,  Vijayalasmi ARUMUGAM ,  Paul KRENITSKY ,  James Philip JOHNSON

IPC: C07C311/46 ,  A61K31/18

CPC classification number: C07C311/46 ,  A61K31/18 ,  C07C2601/02

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及可用作钠通道抑制剂的式I化合物或其药学上可接受的盐：（I）。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括疼痛）的方法。