公开(公告)号：US20130216555A1

公开(公告)日：2013-08-22

申请号：US13717152

申请日：2012-12-17

申请人： University of Zürich

发明人： Roger NITSCH ,  Christoph HOCK ,  Christoph ESSLINGER ,  Marlen KNOBLOCH ,  Kathrin TISSOT ,  Jan GRIMM

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/1018 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/52

摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.