公开(公告)号：US10561741B2

公开(公告)日：2020-02-18

申请号：US15553855

申请日：2016-03-03

Applicant: UNIVERSITY OF MIAMI

Inventor： Paolo Serafini ,  Jennifer Vella ,  Vincenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC: A61K47/69 ,  A61K47/59 ,  A61K47/64 ,  A61P35/00 ,  A61K31/683 ,  A61K31/713 ,  A61K49/00 ,  C12N15/113

Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.

公开(公告)号：US20150139904A1

公开(公告)日：2015-05-21

申请号：US14403107

申请日：2013-05-21

Applicant: University of Miami

Inventor： Omaida Velazquez ,  Sylvia Daunert ,  Pirouz Daftarian ,  Liu Zhao-Jun ,  Sapna Deo

IPC: A61K35/28 ,  A61K47/48 ,  A61K49/00

CPC classification number: A61K47/58 ,  A61K35/28 ,  A61K38/00 ,  A61K47/54 ,  A61K47/6425 ,  A61K49/0004 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70596

Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.

Abstract translation: 本发明提供树枝状聚合物共轭物。 本发明提供包含树枝状聚合物缀合物和细胞的组合物，例如覆盖有树枝状聚合物缀合物的细胞，其中树枝状大分子将细胞接合到靶组织。

公开(公告)号：US11364305B2

公开(公告)日：2022-06-21

申请号：US16792667

申请日：2020-02-17

Applicant: UNIVERSITY OF MIAMI

Inventor： Paolo Serafini ,  Jennifer Vella ,  Vincenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC: A61K47/69 ,  C12N15/113 ,  A61K31/7105 ,  C07K7/06 ,  A61K47/60 ,  A61K38/00

Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a cell.

公开(公告)号：US20220023421A1

公开(公告)日：2022-01-27

申请号：US17404538

申请日：2021-08-17

Applicant: University of Miami

Inventor： Victor L. Perez Quinones ,  Pirouz Daftarian

IPC: A61K39/395 ,  C07K14/47 ,  C12N5/16 ,  A61K47/64 ,  A61K47/59 ,  A61K39/39 ,  A61K47/50 ,  A61P37/00 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00 ,  A61K9/51

Abstract: Conjugates of synthetic nanocarriers, complexed with syngeneic (self) proteins adducted with haptens or other poorly immunogenic antigens (antigens of low immunogenicity), elicit selective humoral responses or antibodies against the hapten or antigen and not to self-protein. Compositions include these conjugates, which can be used as vaccines. Methods of making and using them are described herein. In a typical embodiment, a conjugate including a hapten or antigen of low immunogenicity associated with a particular disease (e.g., infection, cancer) can be used as a vaccine by eliciting antibodies that specifically neutralize the hapten or antigen. These hapten (and other poorly immunogenic antigen)-carrying nanocarriers selectively target antigen presenting cells resulting in a strong anti-hapten humoral response, and thus find use in vaccines for cancer (e.g., cancers of lung, cervix, breast, brain, liver pancreas, ovaries, skin, etc.), infectious diseases and inflammatory-mediated diseases, as well as for autoimmune disorders.

公开(公告)号：US20200237928A1

公开(公告)日：2020-07-30

申请号：US16792667

申请日：2020-02-17

Applicant: UNIVERSITY OF MIAMI

Inventor： Paolo Serafini ,  Jennifer Vella ,  Vincenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC: A61K47/69 ,  C12N15/113 ,  A61K31/7105 ,  A61K47/60 ,  C07K7/06

Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a cell.

公开(公告)号：US20190184013A1

公开(公告)日：2019-06-20

申请号：US16302457

申请日：2017-05-23

Applicant: University of Miami

Inventor： Victor L. Perez Quinones ,  Pirouz Daftarian

IPC: A61K39/395 ,  C07K14/47 ,  A61P31/00 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61K47/50 ,  A61K9/51

CPC classification number: A61K39/39558 ,  A61K9/51 ,  A61K39/39 ,  A61K47/50 ,  A61K47/595 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6031 ,  A61K2039/645 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07K14/47 ,  C12N5/163

Abstract: Conjugates of synthetic nanocarriers, complexed with syngeneic (self) proteins adducted with haptens or other poorly immunogenic antigens (antigens of low immunogenicity), elicit selective humoral responses or antibodies against the hapten or antigen and not to self-protein. Compositions include these conjugates, which can be used as vaccines. Methods of making and using them are described herein. In a typical embodiment, a conjugate including a hapten or antigen of low immunogenicity associated with a particular disease (e.g., infection, cancer) can be used as a vaccine by eliciting antibodies that specifically neutralize the hapten or antigen. These hapten (and other poorly immunogenic antigen)-carrying nanocarriers selectively target antigen presenting cells resulting in a strong anti-hapten humoral response, and thus find use in vaccines for cancer (e.g., cancers of lung, cervix, breast, brain, liver pancreas, ovaries, skin, etc.), infectious diseases and inflammatory-mediated diseases, as well as for autoimmune disorders.

公开(公告)号：US20180050111A1

公开(公告)日：2018-02-22

申请号：US15639473

申请日：2017-06-30

Applicant: UNIVERSITY OF MIAMI

Inventor： Omaida Velazquez ,  Sylvia Daunert ,  Pirouz Daftarian ,  Zhao-Jun Liu ,  Sapna Deo

IPC: C07K14/705 ,  A61K49/00 ,  A61K35/28 ,  A61K38/00

CPC classification number: A61K47/58 ,  A61K35/28 ,  A61K38/00 ,  A61K47/54 ,  A61K47/6425 ,  A61K49/0004 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70596

Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.

公开(公告)号：US11253602B2

公开(公告)日：2022-02-22

申请号：US16567731

申请日：2019-09-11

Applicant: University of Miami

Inventor： Omaida Velazquez ,  Sylvia Daunert ,  Pirouz Daftarian ,  Zhao-Jun Liu ,  Sapna Deo

IPC: A61K47/58 ,  A61K47/64 ,  A61K38/00 ,  A61K47/54 ,  C07K14/705 ,  A61K35/28 ,  A61K49/00

Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.

公开(公告)号：US20180243443A1

公开(公告)日：2018-08-30

申请号：US15553855

申请日：2016-03-03

Applicant: UNIVERSITY OF MIAMI

Inventor： Paolo Serafini ,  Jennifer Vella ,  Vicenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC: A61K47/69 ,  C12N15/113 ,  A61K47/59 ,  A61K49/00 ,  A61K47/64 ,  A61K31/683 ,  A61K31/713 ,  A61P35/00

CPC classification number: A61K47/6935 ,  A61K31/683 ,  A61K31/713 ,  A61K47/595 ,  A61K47/642 ,  A61K49/0004 ,  A61P35/00 ,  C12N15/1135 ,  C12N2310/122 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2310/531

Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.

公开(公告)号：US09737611B2

公开(公告)日：2017-08-22

申请号：US14403107

申请日：2013-05-21

Applicant: University of Miami

Inventor： Omaida Velazquez ,  Sylvia Daunert ,  Pirouz Daftarian ,  Zhao-Jun Liu ,  Sapna Deo

IPC: A61K47/48 ,  A61K49/00 ,  A61K35/28 ,  C07K14/705 ,  A61K38/00

CPC classification number: A61K47/58 ,  A61K35/28 ,  A61K38/00 ,  A61K47/54 ,  A61K47/6425 ,  A61K49/0004 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70596

Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.