公开(公告)号：US11504436B2

公开(公告)日：2022-11-22

申请号：US16608838

申请日：2018-05-17

申请人： University of Massachusetts

发明人： Gang Han ,  Yang Zhao ,  Jing Peng

IPC分类号： A61K49/10

摘要： The invention provides a novel class of MRI contrast agents based on biogenic hemin and compositions and methods of preparation and use thereof.

公开(公告)号：US11369698B2

公开(公告)日：2022-06-28

申请号：US16608837

申请日：2018-05-17

申请人： University of Massachusetts

发明人： Gang Han ,  Yang Zhao

IPC分类号： A61K49/14 ,  A61K49/18

摘要： The invention provides a novel class of clearable, tumor-targeting and human protein-based MRI nanoprobes and contrast agents and their compositions, and methods of preparation and use thereof.

公开(公告)号：US10527548B2

公开(公告)日：2020-01-07

申请号：US16381974

申请日：2019-04-11

申请人： University of Massachusetts

发明人： Gang Han ,  Jie Shen

IPC分类号： A61K9/00 ,  G01N21/64 ,  C09K11/02 ,  C09K11/77

摘要： The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatiable 800 nm excitable property are disclosed herein, for example, tri-doped β-NaYF4:Nd, Yb, Er (Tm)/NaYF4UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

公开(公告)号：US10295467B2

公开(公告)日：2019-05-21

申请号：US14761546

申请日：2014-01-22

申请人： University of Massachusetts Medical School

发明人： Gang Han ,  Jie Shen

IPC分类号： A61K9/00 ,  G01N21/64 ,  C09K11/02 ,  C09K11/77

摘要： The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatible 800 nm excitable property are disclosed herein, for example, tri-doped β-NaYF4:Nd,Yb,Er(Tm)/NaYF4 UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

公开(公告)号：US20220096661A1

公开(公告)日：2022-03-31

申请号：US17467412

申请日：2021-09-06

申请人： University of Massachusetts

发明人： Gang Han ,  Zhanjun Li

IPC分类号： A61K49/00 ,  A61K9/51 ,  C09D11/50 ,  C09D11/106 ,  C09K11/77 ,  G01N21/64

摘要： The invention provides novel nanoparticles with tunable and multi-color afterglow emission for extended time after excitation, and compositions thereof as well as methods for their preparation and use in various applications.

公开(公告)号：US20220002320A1

公开(公告)日：2022-01-06

申请号：US17373354

申请日：2021-07-12

申请人： University of Massachusetts

发明人： Gang Han ,  Ling Huang

IPC分类号： C07F5/02 ,  A61K47/54 ,  A61K47/69 ,  A61K31/196 ,  A61K41/00

摘要： The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.

公开(公告)号：US20190292452A1

公开(公告)日：2019-09-26

申请号：US16402391

申请日：2019-05-03

申请人： University of Massachusetts

发明人： Gang Han ,  Zhanjun Li

IPC分类号： C09K11/68 ,  A61K8/27 ,  A61K9/51 ,  A61Q3/02 ,  A61Q5/06 ,  A61K8/25 ,  C09D5/03 ,  C09D5/22 ,  C09K11/59 ,  G01N33/58 ,  C01G15/00

摘要： This invention provides a groundbreaking approach to PLNPs and their preparation. In particular, the synthetic methodology disclosed herein fundamentally differs from the traditional solid-state annealing reactions that require extreme and harsh reaction conditions. In one unique aspect of the invention, a simple, one-step mesoporous template method utilizing mesoporous silica nanoparticles (MSNs) is disclosed that affords in vivo rechargeable NIR-emitting mesoporous PLNPs with uniform size and morphology. In another unique aspect of the invention, the novel synthetic approach is based on aqueous-phase chemical reactions conducted in mild conditions, resulting in uniform and homogeneous PLNPs with desired size control (e.g., sub-10 nm).

公开(公告)号：US20150238638A1

公开(公告)日：2015-08-27

申请号：US13902298

申请日：2013-05-24

申请人： University of Massachusetts Medical School

发明人： Gang Han ,  Jie Shen

IPC分类号： A61K49/00 ,  C09K11/02 ,  C09K11/77

CPC分类号： A61K49/0019 ,  A61K41/008 ,  A61K49/0052 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y5/00 ,  C01F17/0031 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09K11/025 ,  C09K11/7773

摘要： The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.

摘要翻译： 本发明提供了新颖的生物相容性上转换纳米颗粒（UCNP），其包含立方晶体的核心（例如，包括α-Na Lna，Lnb Lnc F4）和外延壳（例如，由CaF 2形成;其中Lnb是Yb），以及相关方法 的制备和用途。

公开(公告)号：US20220323617A1

公开(公告)日：2022-10-13

申请号：US17734647

申请日：2022-05-02

申请人： University of Massachusetts

发明人： Gang Han ,  Yang Zhao

IPC分类号： A61K49/18 ,  A61K49/14

摘要： The invention provides a novel class of clearable, tumor-targeting and human protein-based MRI nanoprobes and contrast agents and their compositions, and methods of preparation and use thereof.

公开(公告)号：US20220178928A1

公开(公告)日：2022-06-09

申请号：US17602765

申请日：2020-05-21

申请人： University of Massachusetts

发明人： Gang Han

IPC分类号： G01N33/574 ,  C12N15/86

摘要： The invention provides novel genetic probes and bioactive agents and compositions and methods of use thereof in diagnostic and therapeutic applications.