公开(公告)号：US09675820B2

公开(公告)日：2017-06-13

申请号：US15008821

申请日：2016-01-28

申请人： University of Cincinnati

发明人： Christy K. Holland ,  Saurabh Datta ,  T. Douglas Mast ,  Nikolas Ivancevich ,  Kathryn Elizabeth Hitchcock ,  Kevin Haworth

IPC分类号： A61N7/00 ,  A61B8/06 ,  A61B8/08 ,  G01S7/52 ,  A61M37/00 ,  A61B17/22 ,  A61B17/00

CPC分类号： A61N7/00 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/481 ,  A61B17/2202 ,  A61B2017/00172 ,  A61B2017/0019 ,  A61B2017/00194 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61M37/0092 ,  A61N2007/0039 ,  G01S7/52038

摘要： Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.

公开(公告)号：US20160144203A1

公开(公告)日：2016-05-26

申请号：US15008821

申请日：2016-01-28

申请人： University of Cincinnati

发明人： Christy K. Holland ,  Saurabh Datta ,  T. Douglas Mast ,  Nikolas Ivancevich ,  Kathryn Elizabeth Hitchcock ,  Kevin Haworth

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/481 ,  A61B17/2202 ,  A61B2017/00172 ,  A61B2017/0019 ,  A61B2017/00194 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61M37/0092 ,  A61N2007/0039 ,  G01S7/52038

摘要： Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.

摘要翻译： 提供了用于被动地检测稳定气蚀和增强溶栓时稳定气蚀的方法和系统。 被动检测稳定气蚀的方法包括提供确定水平的超声波能量并检测超声能量的分散水平。 用于诱发和被动检测稳定气蚀的系统包括双元件环形换能器阵列，其配置成提供基本超声波频率并检测作为基频的导数的超声波频率。 增强稳定气蚀的方法包括向处理区施用成核剂和溶血栓剂，提供确定水平的超声波能量，以及检测超声能量的分散水平。