公开(公告)号：US11071750B2

公开(公告)日：2021-07-27

申请号：US16471042

申请日：2017-12-21

Applicant: BIOPOLIFE SRL ,  UNIVERSITA' DEGLI STUDI DI TRIESTE

Inventor： Marco Bosco ,  Massimiliano Borgogna ,  Andrea Travan ,  Ivan Donati

IPC: A61K31/722 ,  A61K8/73 ,  A61K33/22

Abstract: Disclosed are adducts of boric acid and chitosan wherein the amino groups of the D-glucosamine units are bonded to residues of polyol or alditol oligosaccharides, the molar ratio between boric acid and the repeating chitosan unit ranging between 0.001 and 4.

公开(公告)号：US09932416B2

公开(公告)日：2018-04-03

申请号：US15121504

申请日：2015-02-26

Applicant: Universita' Degli Studi Di Trieste

Inventor： Sergio Paoletti ,  Roberto Di Lenarda ,  Lorenzo Breschi ,  Milena Cadenaro ,  Marina Diolosa' ,  Gianluca Turco ,  Ivan Donati

IPC: A61L24/08 ,  A61K6/097 ,  C08B37/08 ,  A61K6/083

CPC classification number: C08B37/003 ,  A61K6/083 ,  A61K6/097 ,  A61L24/08 ,  C08L33/08 ,  C08L5/08

Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

公开(公告)号：US20160362503A1

公开(公告)日：2016-12-15

申请号：US15121504

申请日：2015-02-26

Applicant: Universita' Degli Studi Di Trieste

Inventor： Sergio Paoletti ,  Roberto Di Lenarda ,  Lorenzo Breschi ,  Milena Cadenaro ,  Marina Diolosa ,  Gianluca Turco ,  Ivan Donati

IPC: C08B37/08 ,  A61L24/08 ,  A61K6/097

CPC classification number: C08B37/003 ,  A61K6/083 ,  A61K6/097 ,  A61L24/08 ,  C08L33/08 ,  C08L5/08

Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

Abstract translation: 本发明涉及具有丙烯酸基团的壳聚糖的化学改性衍生物的制备及其在釉 - 牙本质粘合剂领域中的应用。 壳聚糖衍生物具有物理化学特征（亲水性，在链上存在电荷），这使得它们与去矿质化牙齿的有机部分相互作用。 同时，掺入聚合物链中的丙烯酸基允许与通常由丙烯酸树脂组成的牙科领域中使用的修复材料形成共价键。 通过结合与牙齿表面的粘附和与修复材料的粘合，本文所述的化学改性的壳聚糖能够增加牙齿修复体的寿命，因此可用于粘合剂领域，特别是牙釉质 - 牙本质粘合剂领域。