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公开(公告)号：US12022823B2
公开(公告)日：2024-07-02
申请号：US16942170
申请日：2020-07-29
Applicant: United Therapeutics Corporation
Inventor： Ryan Bonvillain , John Cheadle , Thomas Petersen
CPC classification number: A01N1/0247 , A61L2/0017 , A61L27/36 , G01G19/00 , G01K13/02 , G01L7/00
Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
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公开(公告)号：US10757932B2
公开(公告)日：2020-09-01
申请号：US15508005
申请日：2015-09-01
Applicant: United Therapeutics Corporation
Inventor： Ryan Bonvillain , John Cheadle , Thomas Peterson
Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
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Patent Agency Ranking
公开(公告)号：US20240315238A1
公开(公告)日：2024-09-26
申请号：US18680636
申请日：2024-05-31
Applicant: United Therapeutics Corporation
Inventor： Ryan Bonvillain , John Cheadle , Thomas Petersen
CPC classification number: A01N1/0247 , A61L2/0017 , A61L27/36 , G01G19/00 , G01K13/02 , G01L7/00
Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
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公开(公告)号：US20180296606A1
公开(公告)日：2018-10-18
申请号：US15967714
申请日：2018-05-01
Applicant: United Therapeutics Corporation
Inventor： Sarah Hogan , Roger Marquez Ilagan , Maria Pia Rodriguez , Carolina Medrano , John Cheadle
IPC: A61K35/28 , A61P9/12 , C12N9/14 , C12N9/12 , C12N5/0775 , C07K14/47 , A61K31/519
Abstract: Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
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公开(公告)号：US20210169939A1
公开(公告)日：2021-06-10
申请号：US17109775
申请日：2020-12-02
Applicant: United Therapeutics Corporation
Inventor： Roger Ilagan , Sarah Hogan , John Cheadle , Carolina Papu
IPC: A61K35/28 , C12N5/0775 , A61P11/00 , A61K9/00 , A61K31/519 , A61P9/12
Abstract: Provided are methods for isolating potent extracellular vesicle populations from mesenchymal stem cells. In particular, the present disclosure identified a protein profile specific for MSC-derived EV populations. Moreover, disclosed herein is the use of the isolated extracellular vesicles in treating a variety of diseases and conditions, including chronic or acute lung diseases such as pulmonary hypertension, ARDS and diseases and conditions characterized by vasculopathy, reduced angiogenesis, apoptosis, mitochondrial dysfunction, acute inflammation, fibrosis, or chronic inflammation.
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公开(公告)号：US10946047B2
公开(公告)日：2021-03-16
申请号：US15967714
申请日：2018-05-01
Applicant: United Therapeutics Corporation
Inventor： Sarah Hogan , Roger Marquez Ilagan , Maria Pia Rodriguez , Carolina Medrano , John Cheadle
IPC: C12N9/14 , A61K35/28 , A61P9/12 , C12N9/12 , C12N5/0775 , C07K14/47 , A61K31/519 , C12N5/071 , C12N5/077 , A61K48/00
Abstract: Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
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公开(公告)号：US20180228144A1
公开(公告)日：2018-08-16
申请号：US15508005
申请日：2015-09-01
Applicant: United Therapeutics Corporation
Inventor： Ryan Bonvillain , John Cheadle , Thomas Peterson
Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
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