公开(公告)号：US11123393B2

公开(公告)日：2021-09-21

申请号：US14305839

申请日：2014-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Bo-Su Lee ,  Young-Chul Lee ,  Breanna Moore ,  Jeong-Bum Nam ,  Mi-Sun Oh ,  Mi-Hye Park ,  Mesfin Yimam ,  Qian Zhang

IPC分类号： A61K36/605 ,  A61K36/48 ,  A61K31/7008 ,  A61K36/534 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7028 ,  A61K31/7034

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

公开(公告)号：US10603270B2

公开(公告)日：2020-03-31

申请号：US15031709

申请日：2014-10-30

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Brandon Corneliusen ,  Mei-Feng Hong ,  Ji-Hye Hwang ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Mi-Ran Kim ,  Bo-Su Lee ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mi-Sun Oh ,  Mesfin Yimam

IPC分类号： A61K8/97 ,  A61Q19/00 ,  A61K8/49 ,  A61Q19/08 ,  A61K8/02 ,  A61Q19/06 ,  A61K8/36

摘要： The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.

公开(公告)号：US20160263013A1

公开(公告)日：2016-09-15

申请号：US15031709

申请日：2014-10-30

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Brandon Corneliusen ,  Mei-Feng Hong ,  Ji-Hye Hwang ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Mi-Ran Kim ,  Bo-Su Lee ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mi-Sun Oh ,  Mesfin Yimam

IPC分类号： A61K8/97 ,  A61K8/02 ,  A61K8/49 ,  A61K8/36 ,  A61Q19/00 ,  A61Q19/06

CPC分类号： A61K8/97 ,  A61K8/0204 ,  A61K8/36 ,  A61K8/4926 ,  A61K8/4973 ,  A61K2800/42 ,  A61K2800/522 ,  A61K2800/5922 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08

摘要： The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.

摘要翻译： 本公开提供糖苹果和迷迭香提取物的混合物，任选地与花椒灰提取物组合用作皮肤护理组合物。

公开(公告)号：US20150072953A1

公开(公告)日：2015-03-12

申请号：US14305839

申请日：2014-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Bo-Su Lee ,  Young-Chul Lee ,  Breanna Moore ,  Jeong-Bum Nam ,  Mi-Sun Oh ,  Mi-Hye Park ,  Mesfin Yimam ,  Qian Zhang

IPC分类号： A61K31/7028 ,  A61K36/48 ,  A61K31/7008 ,  A61K31/352 ,  A61K31/05 ,  A61K36/605 ,  A61K31/353

CPC分类号： A61K36/605 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7034 ,  A61K36/48 ,  A61K36/534 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

摘要翻译： 本公开内容提供了异戊烯酮化的黄酮，二苯乙烯或二者与黄烷或姜黄素或能够调节关节炎症，关节疼痛，关节僵硬，软骨降解或改善移动性，运动范围，柔韧性，关节物理功能或任何 的组合。 这种异戊烯基化黄酮，二苯乙烯或二者与黄烷或姜黄素或二者的混合物可以任选地与其它联合管理剂，例如非甾体抗炎剂/止痛剂，COX / LOX抑制剂，葡糖胺化合物， 神经性疼痛缓解剂等。

公开(公告)号：US20180055899A1

公开(公告)日：2018-03-01

申请号：US15663793

申请日：2017-07-30

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mesfin Yimam

IPC分类号： A61K36/605 ,  A61K36/48 ,  A61K31/352 ,  A61K31/7034

CPC分类号： A61K36/605 ,  A61K9/2054 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7008 ,  A61K31/7034 ,  A61K31/737 ,  A61K36/48 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

公开(公告)号：US20160045559A1

公开(公告)日：2016-02-18

申请号：US14741221

申请日：2015-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mesfin Yimam

IPC分类号： A61K36/605 ,  A61K36/48

CPC分类号： A61K36/605 ,  A61K31/352 ,  A61K31/7034 ,  A61K36/48 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

摘要翻译： 本公开提供了异戊烯酮化的黄酮，二苯乙烯或二者与黄烷或姜黄素或两者的混合物，其可用于促进，管理或改善骨健康，软骨健康或两者，或用于预防或治疗骨病，软骨障碍或两者。 这种异戊烯基化黄酮，二苯乙烯或二者与黄烷或姜黄素或二者的混合物可以任选地与其它骨和软骨管理剂如钙，镁，锌，硼，维生素D，维生素K，葡糖胺和/ 或软骨素化合物，非甾体抗炎剂/止痛剂，COX / LOX抑制剂，神经性疼痛缓解剂等。

公开(公告)号：US09844576B2

公开(公告)日：2017-12-19

申请号：US13904851

申请日：2013-05-29

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Byong-Il Choi ,  Brandon Corneliusen ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Bo-Su Lee ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mesfin Yimam ,  Ji-Hye Hwang ,  Mi-Sun Oh

IPC分类号： A61K36/575 ,  A61K36/37 ,  A61K36/53 ,  A61K36/185 ,  A61K36/752 ,  A61K36/889 ,  A61K36/10 ,  A61K36/258 ,  A61K36/346 ,  A61K36/38 ,  A61K36/56 ,  A61K36/605 ,  A61K36/67 ,  A61K31/352 ,  A61K45/06 ,  A61K31/12 ,  A61K31/343

CPC分类号： A61K36/575 ,  A61K31/12 ,  A61K31/343 ,  A61K31/352 ,  A61K36/10 ,  A61K36/185 ,  A61K36/258 ,  A61K36/346 ,  A61K36/37 ,  A61K36/38 ,  A61K36/53 ,  A61K36/56 ,  A61K36/605 ,  A61K36/67 ,  A61K36/752 ,  A61K36/889 ,  A61K45/06 ,  A61K2300/00

摘要： The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.

公开(公告)号：US09717770B2

公开(公告)日：2017-08-01

申请号：US14741221

申请日：2015-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Hyun-Jin Kim ,  Mi-Ran Kim ,  Tae-Woo Kim ,  Young-Chul Lee ,  Jeong-Bum Nam ,  Mesfin Yimam

IPC分类号： A01N65/00 ,  A61K36/605 ,  A61K31/352 ,  A61K31/7034 ,  A61K36/48

CPC分类号： A61K36/605 ,  A61K31/352 ,  A61K31/7034 ,  A61K36/48 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

公开(公告)号：US20160067296A1

公开(公告)日：2016-03-10

申请号：US14853063

申请日：2015-09-14

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： Lidia Alfaro Brownell ,  Min Chu ,  Mei-Feng Hong ,  Eu-Jin Hyun ,  Qi Jia ,  Ping Jiao ,  Young-Chul Lee ,  Mesfin Yimam

IPC分类号： A61K36/605 ,  A61K31/7034 ,  A61K31/352 ,  A61K31/05 ,  A61K36/48 ,  A61K31/353

CPC分类号： A61K36/605 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7034 ,  A61K36/48 ,  A61K36/534 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

摘要翻译： 本公开内容提供了异戊烯酮化的黄酮，二苯乙烯或二者与黄烷或姜黄素或能够调节关节炎症，关节疼痛，关节僵硬，软骨降解或改善移动性，运动范围，柔韧性，关节物理功能或任何 的组合。 这种异戊烯基化黄酮，二苯乙烯或二者与黄烷或姜黄素或二者的混合物可以任选地与其它联合管理剂，例如非甾体抗炎剂/止痛剂，COX / LOX抑制剂，葡糖胺化合物， 神经性疼痛缓解剂等。

公开(公告)号：US12042523B2

公开(公告)日：2024-07-23

申请号：US18084009

申请日：2022-12-19

申请人： Unigen, Inc.

发明人： Qi Jia ,  Ping Jiao ,  Mesfin Yimam ,  Teresa Horm

IPC分类号： A61K36/00 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7034 ,  A61K36/48 ,  A61K36/605

CPC分类号： A61K36/605 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7034 ,  A61K36/48 ,  A61K2300/00 ,  A61K36/605 ,  A61K2300/00 ,  A61K36/48 ,  A61K2300/00 ,  A61K31/352 ,  A61K2300/00 ,  A61K31/7034 ,  A61K2300/00 ,  A61K31/353 ,  A61K2300/00

摘要： Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.