专利检索 ap:("Ultivue, Inc.") AND inv:"Mark N. Bobrow" 第 1 页

1.

发明授权
Methods and compositions for sequentially detecting targets 有权

公开(公告)号：US11674178B2

公开(公告)日：2023-06-13

申请号：US16713760

申请日：2019-12-13

申请人： Ultivue, Inc.

发明人： Abdul Majeed Mohammed , Mael Manesse , Mack J. Schermer , Mark N. Bobrow , Michael Jules Natan

IPC分类号： C12Q1/6876 , G01N21/76

CPC分类号： C12Q1/6876 , G01N21/76

摘要： Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.

2.

发明公开
Methods and Compositions for Sequentially Detecting Targets 审中-公开

公开(公告)号：US20230313297A1

公开(公告)日：2023-10-05

申请号：US18308706

申请日：2023-04-28

申请人： Ultivue, Inc.

发明人： Abdul Majeed Mohammed , Mael Manesse , Mack J. Schermer , Mark N. Bobrow , Michael Jules Natan

IPC分类号： C12Q1/6876 , G01N21/76

CPC分类号： C12Q1/6876 , G01N21/76

摘要： Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.