公开(公告)号：US20220096724A1

公开(公告)日：2022-03-31

申请号：US17396035

申请日：2021-08-06

申请人： UOP LLC

发明人： Francis Stephen Lupton ,  Gregory J. Lewis ,  James M. Hodges ,  Paulina Jakubczak ,  Mimoza Sylejmani-Rekaliu ,  William Sheets

IPC分类号： A61M1/36 ,  A61M1/28 ,  A61K38/06 ,  A61K31/198 ,  A61K31/194 ,  A61K31/10 ,  A61K31/35 ,  A61K31/44 ,  A61K31/341 ,  A61K31/4184 ,  A61K33/24 ,  B01D15/36 ,  B01D69/08 ,  B01D69/14

摘要： A process for removing Pb2+, Hg2+ and other heavy metal toxins from bodily fluids is disclosed. The process involves treating a patient with a small molecule heavy metal chelator to remove these toxins from bones and soft tissue cells into the blood or other bodily fluid. Then an ion exchange composition is used to ion exchange the heavy metal toxins from bodily fluids either within the body or by treatment outside the body such as by dialysis. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

公开(公告)号：US12121888B2

公开(公告)日：2024-10-22

申请号：US17408575

申请日：2021-08-23

申请人： UOP LLC

发明人： James M. Hodges ,  Mimoza Sylejmani-Rekaliu ,  Paulina Jakubczak ,  Evgeny Kolev ,  Gregory J. Lewis ,  William Sheets

IPC分类号： B01J39/09 ,  B01J39/02 ,  C01B33/20

CPC分类号： B01J39/09 ,  B01J39/02 ,  C01B33/20 ,  C01P2002/72

摘要： A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula:

Ar+pMs+1-xM′t+xSinOm

where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M′ is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.

公开(公告)号：US20240307845A1

公开(公告)日：2024-09-19

申请号：US18677224

申请日：2024-05-29

申请人： UOP LLC

发明人： Gregory J. Lewis ,  Paulina Jakubczak ,  James M. Hodges ,  Evgeny Kolev ,  William Sheets ,  Mimoza Sylejmani-Rekaliu

IPC分类号： B01J20/16 ,  A61M1/36 ,  B01D15/36 ,  B01J20/28

CPC分类号： B01J20/16 ,  A61M1/3679 ,  B01D15/362 ,  B01J20/28026 ,  B01D2257/60

摘要： A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula:


AmTiaNb1-aSixOy

having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

公开(公告)号：US12036528B2

公开(公告)日：2024-07-16

申请号：US17403335

申请日：2021-08-16

申请人： UOP LLC

发明人： Gregory J. Lewis ,  Paulina Jakubczak ,  James M. Hodges ,  Evgeny Kolev ,  William Sheets ,  Mimoza Sylejmani-Rekaliu

IPC分类号： B01J20/16 ,  A61M1/36 ,  B01D15/36 ,  B01J20/28

CPC分类号： B01J20/16 ,  A61M1/3679 ,  B01D15/362 ,  B01J20/28026 ,  B01D2257/60

摘要： A process for removing Pb2+ toxins from bodily fluids involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula:

AmTiaNb1-aSixOy

having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. There are also compositions comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

公开(公告)号：US20220096962A1

公开(公告)日：2022-03-31

申请号：US17406331

申请日：2021-08-19

申请人： UOP LLC

发明人： Mimoza Sylejmani-Rekaliu ,  James M. Hodges ,  Paulina Jakubczak ,  Evgeny Kolev ,  Gregory J. Lewis ,  William Sheets

IPC分类号： B01D15/36 ,  A61M1/28 ,  A61M1/36 ,  A61M31/00 ,  A61K33/06 ,  A61K33/24 ,  A61P3/12 ,  B01D15/20 ,  B01D69/14 ,  B01D69/08 ,  B01J39/02 ,  B01J39/14 ,  B01J47/12

摘要： A process for removing Pb2+, Hg2+, K+ and NH4+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: Ar+pMs+1-xM′t+xSinOm A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

公开(公告)号：US20220097034A1

公开(公告)日：2022-03-31

申请号：US17408575

申请日：2021-08-23

申请人： UOP LLC

发明人： James M. Hodges ,  Mimoza Sylejmani-Rekaliu ,  Paulina Jakubczak ,  Evgeny Kolev ,  Gregory J. Lewis ,  William Sheets

IPC分类号： B01J39/09 ,  B01J39/02 ,  C01B33/20

摘要： A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula: Ar+pMs+1-xM′t+xSinOm where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M′ is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.

公开(公告)号：US20220097019A1

公开(公告)日：2022-03-31

申请号：US17403335

申请日：2021-08-16

申请人： UOP LLC

发明人： Gregory J. Lewis ,  Paulina Jakubczak ,  James M. Hodges ,  Evgeny Kolev ,  William Sheets ,  Mimoza Sylejmani-Rekaliu

IPC分类号： B01J20/16 ,  B01D15/36 ,  B01J20/28 ,  A61M1/36

摘要： A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: AmTiaNb1-aSixOy having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.