公开(公告)号：US20230340570A1

公开(公告)日：2023-10-26

申请号：US18114091

申请日：2023-02-24

Applicant: Ultima Genomics, Inc.

Inventor： Daniel MAZUR ,  Kevin HEINEMANN ,  Theo NIKIFOROV ,  Robert ONO ,  Aklilu WORKU ,  Florian OBERSTRASS

IPC: C12Q1/6811

CPC classification number: C12Q1/6811

Abstract: The present disclosure provides methods, systems, compositions, and kits for reducing particle aggregation and improving sequencing quality. A method for processing particles may comprise the use of a first buffer solution or a second buffer solution. A method for processing particles may comprise the use of a single-strand binding moiety such as a single-strand binding protein.

公开(公告)号：US20200318170A1

公开(公告)日：2020-10-08

申请号：US16822121

申请日：2020-03-18

Applicant: Ultima Genomics, Inc.

Inventor： Linda LEE ,  Steven MENCHEN ,  Theo NIKIFOROV ,  Gilad ALMOGY ,  Florian OBERSTRASS

IPC: C12Q1/6823 ,  C12Q1/6869 ,  C12Q1/6806 ,  G01N21/64

Abstract: The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.

公开(公告)号：US20250059593A1

公开(公告)日：2025-02-20

申请号：US18776428

申请日：2024-07-18

Applicant: ULTIMA GENOMICS, INC.

Inventor： Linda LEE ,  Steven MENCHEN ,  Theo NIKIFOROV ,  Gilad ALMOGY ,  Florian OBERSTRASS

IPC: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6869 ,  G01N21/64

Abstract: The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.

公开(公告)号：US20240167080A1

公开(公告)日：2024-05-23

申请号：US18535267

申请日：2023-12-11

Applicant: ULTIMA GENOMICS, INC.

Inventor： Eliane TREPAGNIER ,  Mark PRATT ,  Theo NIKIFOROV ,  Gilad ALMOGY

IPC: C12Q1/6818 ,  C12Q1/6869

CPC classification number: C12Q1/6818 ,  C12Q1/6869

Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, such as homopolymer sequences or other repeating sequences, to be determined at a higher accuracy and efficiency.

公开(公告)号：US20230332226A1

公开(公告)日：2023-10-19

申请号：US18176418

申请日：2023-02-28

Applicant: Ultima Genomics, Inc.

Inventor： Florian OBERSTRASS ,  Theo NIKIFOROV ,  Mark STAPLETON ,  Daniel MAZUR ,  Gilad ALMOGY ,  Ishminder MANN ,  Chandan SHEE ,  Benjamin SCHROEDER

IPC: C12Q1/6874 ,  C12Q1/6855

CPC classification number: C12Q1/6874 ,  C12Q1/6855

Abstract: The present disclosure provides compositions, methods, and systems for enrichment and analysis of template nucleic acid molecules, e.g., of a biological sample. Further provided herein are methods of using a plurality of unique bead species each comprising a unique set of identical primer molecules.

公开(公告)号：US20230183778A1

公开(公告)日：2023-06-15

申请号：US17985542

申请日：2022-11-11

Applicant: ULTIMA GENOMICS, INC.

Inventor： Eliane TREPAGNIER ,  Mark PRATT ,  Theo NIKIFOROV ,  Gilad ALMOGY

IPC: C12Q1/6818 ,  C12Q1/6869

CPC classification number: C12Q1/6818 ,  C12Q1/6869

Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, such as homopolymer sequences or other repeating sequences, to be determined at a higher accuracy and efficiency.

公开(公告)号：US20240287483A1

公开(公告)日：2024-08-29

申请号：US18651565

申请日：2024-04-30

Applicant: Ultima Genomics, Inc.

Inventor： Daniel MAZUR ,  Eileen Collins TOZER ,  Theo NIKIFOROV ,  Denise Sanchez TOPACIO-HALL

IPC: C12N9/12 ,  C12Q1/6825

CPC classification number: C12N9/1252 ,  C12Q1/6825 ,  C12Y207/07007

Abstract: Mutant nucleic acid polymerases are described herein. Also described are methods for screening or assaying the mutant nucleic acid polymerases.

公开(公告)号：US20220348994A1

公开(公告)日：2022-11-03

申请号：US17712765

申请日：2022-04-04

Applicant: Ultima Genomics, Inc.

Inventor： Linda LEE ,  Steven MENCHEN ,  Theo NIKIFOROV ,  Gilad ALMOGY ,  Florian OBERSTRASS

IPC: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6869 ,  G01N21/64

Abstract: The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.

公开(公告)号：US20210040543A1

公开(公告)日：2021-02-11

申请号：US16936619

申请日：2020-07-23

Applicant: ULTIMA GENOMICS, INC.

Inventor： Eliane TREPAGNIER ,  Mark PRATT ,  Theo NIKIFOROV ,  Gilad ALMOGY

IPC: C12Q1/6818 ,  C12Q1/6869

Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, such as homopolymer sequences or other repeating sequences, to be determined at a higher accuracy and efficiency.