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    Atomic resonance line source lamps and spectrophotometers for use with such lamps
    1.
    发明授权
    Atomic resonance line source lamps and spectrophotometers for use with such lamps 失效
    用于这种灯的原子共振线源灯和分光光度计

    公开(公告)号：US4669879A

    公开(公告)日：1987-06-02

    申请号：US894451

    申请日：1986-08-04

    申请人： Trevor J. Stockdale ,  Peter Morley

    发明人： Trevor J. Stockdale ,  Peter Morley

    IPC分类号： G01J3/10 ,  G01J3/02 ,  G01N21/01 ,  G01N21/31 ,  G01J3/42

    CPC分类号： G01N21/3103

    摘要： The present invention is directed to a lamp assembly for use in atomic absorption spectrometers in which an atomic element hollow cathode lamp assembly has a lamp formed by a hollow cathode electrode and an anode electrode within a sealed envelope. A base structure is attached to the envelope, and located within the base structure is a resistor network consisting of four resistors connected to a common lead and having four plug terminals protruding from the base structure. Two further plug terminals also protruding from the base structure are connected respectively to the cathode and anode electrodes to provide a connecting structure for connecting these electrodes to a lamp power supply. The five plug terminals protruding from the base structure and connected respectively to the resistors and the common lead provide a further connecting structure of the resistor network to a measurement circuit in an atomic absorption spectrophotometer. The resistor network represents the atomic element of the lamp by virtue of two of the resistors, and further, represents a lamp operating current by virtue of the other two resistors. All of the plug terminals are arranged in a conventional octal plug configuration with a boss on the base structure for insuring correct electrical connection.

    摘要翻译： 本发明涉及一种用于原子吸收光谱仪的灯组件，其中原子元件中空阴极灯组件具有由密封外壳内的中空阴极电极和阳极电极形成的灯。 底座结构附接到外壳，并且位于基座结构内的电阻器网络是由连接到公共导线并且具有从基座结构突出的四个插头端子的四个电阻器组成的电阻器网络。 另外从底座结构突出的两个插头端子分别连接到阴极和阳极电极，以提供将这些电极连接到灯电源的连接结构。 从基座结构突出并分别连接到电阻器和公共引线的五个插头端子提供了电阻器网络与原子吸收分光光度计中的测量电路的另外的连接结构。 电阻器网络借助于两个电阻器代表灯的原子元件，并且还通过其它两个电阻器代表灯工作电流。 所有插头端子布置成传统的八角插头结构，在基座结构上具有凸台以确保正确的电连接。

    Atomic resonance line source lamps and spectrophotometers for use with such lamps
    2.
    发明授权
    Atomic resonance line source lamps and spectrophotometers for use with such lamps 失效
    用于这种灯的原子共振线源灯和分光光度计

    公开(公告)号：US4645343A

    公开(公告)日：1987-02-24

    申请号：US617069

    申请日：1984-06-04

    申请人： Trevor J. Stockdale ,  Peter Morley

    发明人： Trevor J. Stockdale ,  Peter Morley

    IPC分类号： G01N21/31 ,  G01J3/42

    CPC分类号： G01N21/3103 ,  G01N2021/3114

    摘要： An improved source lamp assembly for use in atomic absorption spectrophotometers is described having encoded structures for identifying the atomic element of the source lamp assembly, as well as to represent lamp operating current. The encoding structures are formed by way of mechanical, optical, or magnetic means. In particular, a mechanical arrangement involves a plurality of projections and recesses, either formed relative to a base structure of the lamp assembly or relative to an attached card-like structure. A card reading device is used to read this card-like structure. These alternative arrangements can be also used relative to optical encoding or magnetic encoding.

    摘要翻译： 描述了用于原子吸收分光光度计的改进的源灯组件，其具有用于识别源灯组件的原子元件的编码结构以及表示灯工作电流。 编码结构通过机械，光学或磁性方式形成。 特别地，机械装置包括多个突起和凹部，其相对于灯组件的基座结构或相对于附接的卡状结构形成。 卡读取装置用于读取这种卡状结构。 这些替代布置也可以相对于光编码或磁编码使用。

    Modem backplane interconnections
    3.
    发明授权
    Modem backplane interconnections 失效
    调制解调器背板互连

    公开(公告)号：US4831634A

    公开(公告)日：1989-05-16

    申请号：US219941

    申请日：1988-07-15

    申请人： Lance McNally ,  Peter Morley

    发明人： Lance McNally ,  Peter Morley

    IPC分类号： H05K7/14

    CPC分类号： H05K7/1459

    摘要： Data communication equipment, including relay modules and MODEMS, are mounted on etched back planes. Etched conductors transfer communication line signal pairs to the relay modules, from the relay modules to the MODEMS and from the MODEMS to an output connector. Ribbon cables plugged into the output connectors transfer the MODEM output signals to logic boards, which are plugged into an etched VME bus panel. CPU's plugged into the etched VME bush panel receive signals from and transfer signals to the etched VME bus.

    摘要翻译： 包括继电器模块和MODEMS在内的数据通信设备安装在蚀刻后的平面上。 蚀刻导体将通信线信号对传输到继电器模块，从继电器模块到MODEMS，并从MODEMS到输出连接器。 插入输出连接器的带状电缆将MODEM输出信号传输到逻辑板，这些逻辑板插入蚀刻的VME总线面板。 CPU插入蚀刻的VME衬套面板接收信号并将信号传输到蚀刻的VME总线。

    Spectrophotometer having wavelength selecting structure
    4.
    发明授权
    Spectrophotometer having wavelength selecting structure 失效
    分光光度计具有波长选择结构

    公开(公告)号：US4519706A

    公开(公告)日：1985-05-28

    申请号：US458123

    申请日：1983-01-14

    申请人： Peter Morley ,  Peter J. Little

    发明人： Peter Morley ,  Peter J. Little

    IPC分类号： G01J3/28 ,  G01N21/27 ,  G01N21/31 ,  G01J1/42 ,  G01N21/71

    CPC分类号： G01N21/274 ,  G01N21/3103

    摘要： In atomic spectrophotometers comprising a source of radiation characteristic of an element to be detected in a sample, a monochromator for selecting a desired spectral line from radiation received from the source by the sample, and a detector for producing an output signal from the monochromator output radiation, the monochromator is accurately tuned to the desired line to obtain a maximum detector signal, and simultaneously, the gain of the detector is adjusted to keep the signal magnitude within the best working range of subsequent signal processing circuits. In accordance with the present invention, both adjustments are made simultaneously by comparing an amplified detector signal with a desired reference signal level corresponding to the best signal magnitude, and using the difference between them to adjust the gain of the amplified detector signal in a closed loop control system to continuously equalize the amplified detector signal with the reference level. The monochromator is tuned, preferably by an automatic device, to seek a minimum value of amplifier gain, at which the detector output will be a maximum at the peak of the spectral line with the amplified detector output being simultaneously equal to the desired reference level. The amplifier gain is then set to the values so obtained by a digital-analog converter, and absorption measurements are made with the control loop open.

    摘要翻译： 在包含样品中待检测元件的辐射特性源的原子分光光度计中，用于从样品从源接收的辐射中选择所需谱线的单色仪，以及用于产生来自单色仪输出辐射的输出信号的检测器 ，单色仪被精确地调谐到所需的线以获得最大检测器信号，并且同时调节检测器的增益以将信号幅度保持在后续信号处理电路的最佳工作范围内。 根据本发明，通过将放大的检测器信号与对应于最佳信号幅度的期望参考信号电平进行比较并且使用它们之间的差来调节放大的检测器信号在闭环中的增益来同时进行两个调整 控制系统连续地将放大的检测器信号与参考电平相等。 优选地通过自动装置来调谐单色器，以寻找放大器增益的最小值，在该最小值处，检波器输出将在频谱线的峰值处为最大值，放大的检测器输出同时等于期望的参考电平。 然后将放大器增益设置为由数模转换器获得的值，并且通过控制回路打开进行吸收测量。

    Pharmaceutical care of patients and documentation system therefor
    7.
    发明申请
    Pharmaceutical care of patients and documentation system therefor 审中-公开
    患者的药物护理及其文件系统

    公开(公告)号：US20060271405A1

    公开(公告)日：2006-11-30

    申请号：US11415820

    申请日：2006-05-02

    申请人： Robert Cipolle ,  Linda Strand ,  Peter Morley ,  Thomas Kellenberger ,  Michael Frakes

    发明人： Robert Cipolle ,  Linda Strand ,  Peter Morley ,  Thomas Kellenberger ,  Michael Frakes

    IPC分类号： G06F19/00 ,  G06Q40/00 ,  G06F7/00

    CPC分类号： G06F19/3456 ,  G06Q40/08 ,  G06Q50/24 ,  G16H10/60 ,  G16H50/70

    摘要： A pharmaceutical care practitioner has a n ongoing relationship with a patient in a series of encounters. The practitioner generates an assessment, including demographics of the patient, resulting in a set of indications for pharmacotherapy. The practitioner evaluates medications for appropriateness, effectiveness, safety, and compliance, and recommends or selects medications (including dosage, duration, frequency, etc.) for each indication in a care plan. The practitioner evaluates outcomes from the medications. Items from the assessment, plan, or outcomes are coded as searchable terms in a patient database employed by the practitioner for generating the care plan. The patient database may be consolidated among many different practitioners for greater statistical power. Agreements between practitioners and third-party providers may permit practitioners to override or allow actions not normally permitted by patients' plans, such as drug substitution, dosage adjustment, or choice of source. A computer-based documentation system accesses or contains databases such as patient information, medication products, legal criteria, or insurance criteria. The system may also produce documents or reports, such as care plans, assessments, claims, invoices, statistical analyses, or practice guidelines.

    摘要翻译： 药物保健从业人员在一系列遭遇中与病人有不断的关系。 从业者产生评估，包括患者的人口统计学，产生一组用于药物治疗的适应症。 从业者评估适合性，有效性，安全性和合规性的药物，并在护理计划中推荐或选择每种适应症的药物（包括剂量，持续时间，频率等）。 从业者评估药物的结果。 来自评估，计划或结果的项目被编码为由从业者用于产生护理计划的患者数据库中的可搜索术语。 患者数据库可以在许多不同的从业者中巩固，以获得更大的统计能力。 从业人员和第三方提供者之间的协议可能会让从业者超越或允许患者计划通常不允许的行为，如药物替代，剂量调整或来源选择。 基于计算机的文档系统访问或包含数据库，如患者信息，药品，法律标准或保险标准。 该系统还可以生成文件或报告，例如护理计划，评估，索赔，发票，统计分析或实践指南。

    MODIFIED PROTEINS AND PEPTIDES
    8.
    发明申请
    MODIFIED PROTEINS AND PEPTIDES 审中-公开
    改性蛋白和肽

    公开(公告)号：US20140227259A1

    公开(公告)日：2014-08-14

    申请号：US14239196

    申请日：2012-08-13

    申请人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

    发明人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

    IPC分类号： C07K16/42

    摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

    摘要翻译： 本公开涉及具有降低与先前存在的抗体结合的能力的修饰的蛋白质和肽。 这种修饰的蛋白质/肽分子可以包含C-末端添加，延伸或标签和/或某些氨基酸取代。 这样的修饰分子（例如，融合物和缀合物）包含蛋白质，肽，抗原结合分子，抗体或抗体片段，例如单可变结构域。 本公开还涉及包含这种修饰的C-末端延伸和/或氨基酸取代的分子的组合物的用途和制剂，以及这些的生产和表达方法。