公开(公告)号：US20160008295A1

公开(公告)日：2016-01-14

申请号：US14798807

申请日：2015-07-14

申请人： TissueTech, Inc.

发明人： Scheffer TSENG ,  Sean TIGHE

IPC分类号： A61K31/045 ,  A61K47/10 ,  A61K47/38 ,  A61K47/34 ,  A61K45/06 ,  A61K9/70

CPC分类号： A61K31/045 ,  A61K9/0014 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/34 ,  A61K47/38

摘要： The present invention relates to terpine-4-ol containing pharmaceutical compositions, dermatological delivery systems and methods of treatment that are useful for treating rosacea, to include ocular rosacea, papulopustular rosacea, phymatous rosacea, acne rosacea, rosacea associated with Demodex infections, erythematelangiectatic rosacea, steroid induced rosacea, and combinations thereof, acne vulgaris and related conditions in a patient in need thereof.

摘要翻译： 本发明涉及含萜烯-4-醇的药物组合物，可用于治疗酒渣鼻的皮肤病学输送系统和治疗方法，包括眼酒渣鼻，葡萄糖喷发性红斑痤疮，幽门型酒渣鼻，痤疮性红斑痤疮，与Demodex感染相关的红斑痤疮，红斑狼疮红斑痤疮 ，类固醇诱导的红斑痤疮及其组合，寻常痤疮和有需要的患者中的相关病症。

公开(公告)号：US20200308219A1

公开(公告)日：2020-10-01

申请号：US16898309

申请日：2020-06-10

申请人： TissueTech, Inc.

发明人： Scheffer TSENG ,  Hua HE ,  Sean TIGHE ,  Suzhen ZHANG ,  Ying-Tieng ZHU

IPC分类号： C07K1/36 ,  C07K14/47 ,  A61K47/69 ,  A61K38/19 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07K14/525 ,  C07K19/00 ,  A61K47/55

摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

公开(公告)号：US20190169231A1

公开(公告)日：2019-06-06

申请号：US16274123

申请日：2019-02-12

申请人： TissueTech, Inc.

发明人： Scheffer TSENG ,  Hua HE ,  Sean TIGHE ,  Suzhen ZHANG ,  Ying-Tieng ZHU

IPC分类号： C07K1/36 ,  C07K19/00 ,  A61L27/54 ,  A61K47/55 ,  A61L31/16 ,  C07K14/47 ,  A61L31/10 ,  A61L27/34 ,  A61K47/69 ,  A61L29/16 ,  A61L29/08 ,  C07K14/525 ,  A61K38/19

摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

公开(公告)号：US20230083005A1

公开(公告)日：2023-03-16

申请号：US17798421

申请日：2021-02-12

申请人： TISSUETECH, INC.

发明人： Scheffer TSENG ,  Hua HE ,  Sean TIGHE ,  Kaustuv BASU

IPC分类号： A61K47/62 ,  A61K47/61 ,  A61K45/06 ,  A61P35/00 ,  A61P13/08

摘要： Provided herein, in certain embodiments, are compositions comprising an isolated heavy chain-hyaluronan/pentraxin 3 (“HC-HA/PTX3”) complex for use in methods of killing cancer cells. Also provided herein, are methods of inhibiting cancer cell regrowth of a tumor in an individual in need thereof, comprising contacting an area surrounding the tumor after a surgical procedure with an isolated HC-HA/PTX3 complex. Combinations and kits for use in practicing said methods also are provided herein.

公开(公告)号：US20160376305A1

公开(公告)日：2016-12-29

申请号：US15214706

申请日：2016-07-20

申请人： TissueTech, Inc.

发明人： Scheffer TSENG ,  Hua HE ,  Sean TIGHE ,  Suzhen ZHANG ,  Ying-Tieng ZHU

IPC分类号： C07K1/36 ,  C07K19/00 ,  C07K14/47

CPC分类号： C07K1/36 ,  A61K38/00 ,  A61K38/191 ,  A61K47/55 ,  A61K47/69 ,  A61K47/6957 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/426 ,  C07K14/47 ,  C07K14/525 ,  C07K14/81 ,  C07K19/00

摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

公开(公告)号：US20240000704A1

公开(公告)日：2024-01-04

申请号：US17914691

申请日：2021-04-02

申请人： TissueTech, Inc.

发明人： Scheffer TSENG ,  Sean TIGHE ,  Ek Kia TAN ,  Jason Eric VEVODA

IPC分类号： A61K9/00 ,  A61K35/51 ,  A61P27/02 ,  A61K35/50 ,  A61K45/06

CPC分类号： A61K9/0051 ,  A61K35/51 ,  A61P27/02 ,  A61K35/50 ,  A61K45/06

摘要： Disclosed herein are methods of treating an ocular surface disease, disorder, or wound comprising applying an umbilical cord sheet and/or a controlled-release formulation to a tissue or surrounding tissue of an eye of a subject, such as the inferior fornix, superior fornix, and/or cornea. Further disclosed herein are kits for treatment of an ocular surface disease, disorder, or wound comprising the umbilical cord sheet and/or controlled-release formulation and a device for delivering and applying the umbilical cord sheet and/or controlled-release formulation to an eye of a subject.