公开(公告)号：US20120196277A1

公开(公告)日：2012-08-02

申请号：US13443326

申请日：2012-04-10

Applicant: Timothy M. BLOCK ,  Mary Ann COMUNALE ,  Anand MEHTA

Inventor： Timothy M. BLOCK ,  Mary Ann COMUNALE ,  Anand MEHTA

IPC: G01N33/566 ,  G01N33/574 ,  G01N33/569

CPC classification number: G01N33/6893 ,  G01N33/57438 ,  G01N2333/4728 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/7028

Abstract: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values for the binding of lectin of such proteins in healthy or disease states.

Abstract translation: 公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。 所述方法包括定量地检测凝集素结合生物流体中的蛋白质，并将检测到的凝集素结合与在健康或疾病状态下这些蛋白质的凝集素结合的参考值进行比较。

公开(公告)号：US20130203092A1

公开(公告)日：2013-08-08

申请号：US13388971

申请日：2012-02-03

Applicant: Patrick Robert ROMANO ,  Anand MEHTA ,  Timothy M. Block

Inventor： Patrick Robert ROMANO ,  Anand MEHTA ,  Timothy M. Block

IPC: G01N21/64 ,  G01N33/566 ,  C07K14/42

CPC classification number: G01N33/6893 ,  C07K14/42 ,  G01N33/68 ,  G01N33/6842 ,  G01N2333/42 ,  G01N2400/00

Abstract: The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.

公开(公告)号：US20150198610A9

公开(公告)日：2015-07-16

申请号：US13388971

申请日：2012-02-03

Applicant: Patrick Robert ROMANO ,  Anand MEHTA ,  Timothy M. Block

Inventor： Patrick Robert ROMANO ,  Anand MEHTA ,  Timothy M. Block

IPC: G01N33/68 ,  C07K14/42 ,  G01N33/566

CPC classification number: G01N33/6893 ,  C07K14/42 ,  G01N33/68 ,  G01N33/6842 ,  G01N2333/42 ,  G01N2400/00

Abstract: The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.

Abstract translation: 本发明提供了用于评估蛋白质糖蛋白作为疾病生物标志物的方法，组合物，装置和试剂盒。 使用纯化的重组形式的凝集素作为检测分子来特异性标记在疾病状态中表达的目标糖。 重组凝集素的高亲和力允许自动化将用于诊断疾病例如但不限于癌症或肝脏疾病的测定。