Non-steroidal ligands for the glucocorticoid receptor, and compositions thereof
    1.
    发明授权
    Non-steroidal ligands for the glucocorticoid receptor, and compositions thereof 有权
    糖皮质激素受体的非甾体配体及其组合物

    公开(公告)号:US07947726B2

    公开(公告)日:2011-05-24

    申请号:US12365106

    申请日:2009-02-03

    IPC分类号: A61K31/416 C07D231/54

    摘要: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

    摘要翻译: 本发明提供了用于糖皮质激素受体的非甾体配体,用于制备糖皮质激素受体的非甾体配体的方法,糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病(例如,肥胖症,糖尿病,抑郁症,神经变性或炎性疾病)的糖皮质激素受体。

    Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
    2.
    发明授权
    Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof 失效
    用于糖皮质激素受体的非甾体配体,其组合物和用途

    公开(公告)号:US06831093B2

    公开(公告)日:2004-12-14

    申请号:US10350260

    申请日:2003-01-22

    IPC分类号: A61K31415

    摘要: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

    摘要翻译: 本发明提供了用于糖皮质激素受体的非甾体配体,用于制备糖皮质激素受体的非甾体配体的方法,糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病(例如,肥胖症,糖尿病,抑郁症,神经变性或炎性疾病)的糖皮质激素受体。

    NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF
    3.
    发明申请
    NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF 审中-公开
    GLUCOCORTICOID受体的非甾体配体,组合物及其用途

    公开(公告)号:US20110218225A1

    公开(公告)日:2011-09-08

    申请号:US13105349

    申请日:2011-05-11

    摘要: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

    摘要翻译: 本发明提供了用于糖皮质激素受体的非甾体配体,用于制备糖皮质激素受体的非甾体配体的方法,糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病(例如,肥胖症,糖尿病,抑郁症,神经变性或炎性疾病)的糖皮质激素受体。

    Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof
    4.
    发明申请
    Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof 有权
    用于糖皮质激素受体的非甾体配体,组合物和用途

    公开(公告)号:US20090137655A1

    公开(公告)日:2009-05-28

    申请号:US12365106

    申请日:2009-02-03

    IPC分类号: A61K31/416 C07D231/56

    摘要: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

    摘要翻译: 本发明提供了用于糖皮质激素受体的非甾体配体,用于制备糖皮质激素受体的非甾体配体的方法,糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病(例如,肥胖症,糖尿病,抑郁症,神经变性或炎性疾病)的糖皮质激素受体。

    Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
    5.
    发明授权
    Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof 失效
    用于糖皮质激素受体的非甾体配体,其组合物和用途

    公开(公告)号:US07485660B2

    公开(公告)日:2009-02-03

    申请号:US10972250

    申请日:2004-10-22

    IPC分类号: A61K31/416 C07D231/54

    摘要: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

    摘要翻译: 本发明提供了用于糖皮质激素受体的非甾体配体,用于制备糖皮质激素受体的非甾体配体的方法,糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病(例如,肥胖症,糖尿病,抑郁症,神经变性或炎性疾病)的糖皮质激素受体。

    Host Detection by Top of Rack Switch Devices in Data Center Environments
    7.
    发明申请
    Host Detection by Top of Rack Switch Devices in Data Center Environments 有权
    主机检测数据中心环境中的机架开关设备

    公开(公告)号:US20140064104A1

    公开(公告)日:2014-03-06

    申请号:US13598917

    申请日:2012-08-30

    IPC分类号: H04L12/24 H04L12/56 H04L12/26

    摘要: Techniques are provided for detecting and identifying host devices in a network. At a switch device, a packet is received from a server that is interfaced with a switch device and is configured to host a virtual machine that is a source of the packet. A Media Access Control (MAC) address or an Internet Protocol (IP) address is identified. The MAC address and IP address are associated with the virtual machine. In response to identifying the MAC or IP addresses, the switch device determines whether a binding between the IP and MAC addresses of the virtual machine is present in a database of addresses accessible by the switch device. If the association is not present, based on the fields obtained from the packet header, a request message is sent to the virtual machine to resolve the association between the IP address and the MAC address of the virtual machine.

    摘要翻译: 提供了用于检测和识别网络中的主机设备的技术。 在交换机设备处,从与交换机设备接口的服务器接收分组,并且被配置为托管作为分组的源的虚拟机。 识别媒体访问控制(MAC)地址或互联网协议(IP)地址。 MAC地址和IP地址与虚拟机相关联。 响应于识别MAC或IP地址,交换机设备确定虚拟机的IP和MAC地址之间的绑定是否存在于由交换设备可访问的地址的数据库中。 如果关联不存在,则基于从分组头获得的字段,向虚拟机发送请求消息以解决虚拟机的IP地址和MAC地址之间的关联。

    Electronic trading post
    9.
    发明申请
    Electronic trading post 审中-公开
    电子交易站

    公开(公告)号:US20070198365A1

    公开(公告)日:2007-08-23

    申请号:US11656142

    申请日:2007-01-19

    IPC分类号: G06Q30/00

    CPC分类号: G06Q30/06 G06Q30/0601

    摘要: A method and system for on-line trading and selling, e.g., in an on-line auction, are disclosed. The system provides a polytopic market data (PMD) database for use in spotting fraudulent or suspicions items for sale or trade. The system may include a Sale-it-Now feature that uses historical price data and time-to-respond values to encourage bidding close price levels at or close to historical highs. The system may include a Pareto Sale feature for multiple agents, to identify groups of stable trading arrangements. The system may include Alerts for alerting buyers, sellers or traders in the system to selling, buying, or trading opportunities.

    摘要翻译: 公开了一种用于在线交易和销售的方法和系统,例如在线拍卖。 该系统提供了一个多元市场数据(PMD)数据库,用于发现欺诈或怀疑物品进行销售或交易。 该系统可以包括“销售现在”功能,其使用历史价格数据和时间响应值来鼓励在历史最高点附近或接近历史高位的投标价格水平。 该系统可以包括用于多个代理的帕累托销售功能,以识别稳定交易安排的组。 该系统可以包括用于警告系统中的买方,卖方或交易者进行销售,购买或交易机会的警报。