公开(公告)号：US08788215B2

公开(公告)日：2014-07-22

申请号：US13621311

申请日：2012-09-17

申请人： The University of Tennessee Research Foundation

发明人： Ranajit Chakraborty ,  John Douglas Birdwell ,  Tse-Wei Wang ,  Dale V. Stansberry

IPC分类号： G01N33/50 ,  G06F19/18

CPC分类号： G06F19/18

摘要： The present invention provides a method of predicting whether an unknown biological specimen originates from a member of a particular family. The method compares DNA profiles from at least one unknown biological specimen to DNA profiles of more than one family member, which significantly increases the methods' predictive ability. In particular, the invention describes a method of comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from biological specimens of family members. In one embodiment, a modified Elston Stewart algorithm is used to determine a probability that a genetic relationship exists between at least one unknown biological specimen and the family pedigree.

摘要翻译： 本发明提供一种预测未知生物样品是否源自特定家族成员的方法。 该方法将来自至少一个未知生物标本的DNA谱与多于一个家族成员的DNA谱进行比较，从而显着提高了方法的预测能力。 特别地，本发明描述了将来自未知生物标本的测试DNA谱与家族谱系进行比较的方法，该方法包括从家族成员的生物标本获得的靶DNA谱。 在一个实施例中，使用修改的Elston Stewart算法来确定在至少一个未知生物样本和家族血统之间存在遗传关系的概率。