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1.发明申请Method and Apparatus For Magnetic Susceptibility Tomography, Magnetoencephalography, and Taggant Or Contrast Agent Detection 有权用于磁敏感层析成像，磁脑图，标记或对比剂检测的方法和装置公开(公告)号：US20150219732A1
公开(公告)日：2015-08-06
申请号：US14420828
申请日：2013-08-23
CPC分类号： G01R33/16 , A61B5/0042 , A61B5/04008 , A61B5/0522 , A61B2562/0223 , G01N27/72
摘要： A magnetic susceptibility tomographic device has sensitive magnetic sensors about a measurement volume and AC bias coils for providing magnetic fields within the volume. Sensing circuitry reads the sensors, and a processor executes magnetic susceptibility tomography (MST) routines from memory to divide the measurement volume into voxels, to determine differences between applied and measured field strengths of magnetic fields at each voxel and thereby determines magnetic susceptibility of each voxel, and to construct tomographic images representative of magnetic susceptibility as MST images. Embodiments with SQUID and fluxgate sensors are described. Applications to direct measurement of tissue magnetic susceptibility, and to locating and quantifying tagged magnetic nanoparticles are disclosed, including antibody-tagged nanoparticles for use in cancer diagnosis and treatments, and the retrieval of taggant identification codes from an object.
摘要翻译： 磁化物断层摄影装置具有关于测量体积的敏感磁传感器和用于在体积内提供磁场的AC偏置线圈。 感测电路读取传感器，并且处理器执行来自存储器的磁化率层析成像（MST）程序，以将测量体积划分为体素，以确定每个体素上的磁场的施加和测量场强之间的差异，从而确定每个体素的磁化率 并构建代表磁化率的断层图像作为MST图像。 描述具有SQUID和磁通门传感器的实施例。 公开了用于直接测量组织磁化率的应用，以及定位和定量标记的磁性纳米颗粒，包括用于癌症诊断和治疗的抗体标记的纳米颗粒，以及从对象检索标记物识别码。
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2.发明申请公开(公告)号：US20170067972A1
公开(公告)日：2017-03-09
申请号：US15309201
申请日：2015-05-06
CPC分类号： G01R33/1276 , A61B5/0515 , A61N1/403
摘要： A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.
摘要翻译： 磁性纳米颗粒成像系统具有以多个频率驱动的驱动线圈，驱动线圈定位成向成像区域提供磁场和场梯度，以及静态偏置磁场磁体，其定位成为成像提供静态磁场和/或场梯度 区。 磁传感器被定位成感测来自成像区域的磁场，并且信号处理器处理来自传感器的信号，以在多个频率的谐波和/或互调产物处至少找到信号幅度和相位。 在实施例中，信号处理设备还确定第一频率的至少第二和第三谐波的信号幅度和相位，并且基于互调产物的谐波和幅度的大小来映射纳米颗粒在成像区域中的位置。
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公开(公告)号：US20160270686A1
公开(公告)日：2016-09-22
申请号：US15167773
申请日：2016-05-27
CPC分类号： A61B5/05 , A61B5/4244 , A61B5/4504 , A61B2562/0223 , G01R33/0354 , G01R33/16
摘要： A system for magnetic assessment of body iron stores includes excitation coils adapted to generate multiple-frequency alternating current (AC) magnetic fields and to partially magnetically saturate iron. The system further includes one or more detection coils adapted to detect the AC magnetic fields. A signal processor uses lock-in amplifiers and linear regression to measures changes to the multiple-frequency AC magnetic fields caused by proximity to iron. A method for magnetic assessment of body iron stores includes generating multiple-frequency AC magnetic fields and detecting changes to the AC magnetic fields caused by proximity to iron. The method further includes partially magnetically saturating iron, thereby generating non-linear responses, harmonic frequencies, and intermodulation frequencies.
摘要翻译： 用于身体铁店的磁性评估的系统包括适于产生多频交流（AC）磁场并部分地使铁饱和的励磁线圈。 该系统还包括适于检测AC磁场的一个或多个检测线圈。 信号处理器使用锁定放大器和线性回归来测量由接近铁引起的多频交流磁场的变化。 一种用于身体铁存储器的磁性评估的方法包括产生多频交流磁场并检测由靠近铁引起的交流磁场的变化。 该方法还包括部分磁饱和铁，从而产生非线性响应，谐波频率和互调频率。
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4.发明授权公开(公告)号：US09964608B2
公开(公告)日：2018-05-08
申请号：US15309201
申请日：2015-05-06
CPC分类号： G01R33/1276 , A61B5/0515 , A61N1/403
摘要： A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.
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5.发明授权Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection 有权用于磁化率层析成像，脑磁图和标记剂或造影剂检测的方法和装置公开(公告)号：US09395425B2
公开(公告)日：2016-07-19
申请号：US14420828
申请日：2013-08-23
CPC分类号： G01R33/16 , A61B5/0042 , A61B5/04008 , A61B5/0522 , A61B2562/0223 , G01N27/72
摘要： A magnetic susceptibility tomographic device has sensitive magnetic sensors about a measurement volume and AC bias coils for providing magnetic fields within the volume. Sensing circuitry reads the sensors, and a processor executes magnetic susceptibility tomography (MST) routines from memory to divide the measurement volume into voxels, to determine differences between applied and measured field strengths of magnetic fields at each voxel and thereby determines magnetic susceptibility of each voxel, and to construct tomographic images representative of magnetic susceptibility as MST images. Embodiments with SQUID and fluxgate sensors are described. Applications to direct measurement of tissue magnetic susceptibility, and to locating and quantifying tagged magnetic nanoparticles are disclosed, including antibody-tagged nanoparticles for use in cancer diagnosis and treatments, and the retrieval of taggant identification codes from an object.
摘要翻译： 磁化物断层摄影装置具有关于测量体积的敏感磁传感器和用于在体积内提供磁场的AC偏置线圈。 感测电路读取传感器，并且处理器执行来自存储器的磁化率层析成像（MST）程序，以将测量体积划分为体素，以确定每个体素上的磁场的施加和测量场强之间的差异，从而确定每个体素的磁化率 并构建代表磁化率的断层图像作为MST图像。 描述具有SQUID和磁通门传感器的实施例。 公开了用于直接测量组织磁化率的应用，以及定位和定量标记的磁性纳米颗粒，包括用于癌症诊断和治疗的抗体标记的纳米颗粒，以及从对象检索标记物识别码。
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