公开(公告)号：US12054463B2

公开(公告)日：2024-08-06

申请号：US16646630

申请日：2018-10-30

申请人： The Trustees of Columbia University in the City of New York

发明人： Dileep Kumar ,  J. John Mann ,  Akiva Mintz ,  Kiran Kumar Solingapuram Sai

IPC分类号： C07D239/94 ,  A61K51/04 ,  C07B59/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

CPC分类号： C07D239/94 ,  A61K51/0459 ,  C07B59/002 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

摘要： The present disclosure relates to radiolabeled compounds and methods of uses for diagnosis, monitoring, and treatment of various degenerative neurological disorders, neuropsychiatric disorders, brain injuries, vascular diseases, and cancers. Radiolabled compounds for imaging of microtubules or microtubules and other targets using positron-emission tomography (PET) are specifically disclosed.

公开(公告)号：US20210059590A1

公开(公告)日：2021-03-04

申请号：US16961769

申请日：2019-01-14

申请人： The Trustees of Columbia University in the City of New York

发明人： Mate Istvan Milak ,  J. John Mann

IPC分类号： A61B5/16 ,  A61K33/00 ,  A61K31/135 ,  A61K45/06 ,  A61P25/24 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00

摘要： This invention relates to the field of treatment, prevention, and identification of persons at high risk of developing major depressive disorder based upon elevated concentration of serotonin 1A receptors (i.e., elevated serotonin 1A receptor binding potential). In particular, the current invention identifies offspring of parents with major depressive disorder who are at significantly elevated risk of developing major depressive disorder before any symptoms have occurred and treats these patients prior to any symptoms and more importantly before developing major depressive disorder. The invention also relates to the identification of persons who have discontinued treatment for major depressive disorder based upon elevated concentration of serotonin 1A receptors (i.e., elevated serotonin 1A receptor binding potential).