公开(公告)号：US11360092B2

公开(公告)日：2022-06-14

申请号：US16321577

申请日：2017-08-04

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ,  KDX DIAGNOSTICS, INC.

发明人： Kenneth R. Shroyer ,  Luisa F. Escobar-Hoyos ,  Nam Kim

IPC分类号： G01N33/574 ,  G01N33/569 ,  C12Q1/6886

摘要： The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.

公开(公告)号：US11092603B2

公开(公告)日：2021-08-17

申请号：US15771754

申请日：2016-10-27

申请人： The Research Foundation for The State University of New York

发明人： Kenneth R. Shroyer ,  Luisa F. Escobar-Hoyos

IPC分类号： G01N33/574 ,  C07K16/30 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q1/68 ,  G01N33/541

摘要： The instant application relates to methods for determining pancreatic cancer patient outcome and directing treatment to subjects with pancreatic cancer. The present disclosure further provides methods for measuring expression levels of cytokeratin 17 in a subject having pancreatic cancer, such as pancreatic ductal adenocarcinoma, in order to determine the subject's survival rate and clinical outcome.

公开(公告)号：US20180059112A1

公开(公告)日：2018-03-01

申请号：US15804001

申请日：2017-11-06

申请人： The Research Foundation for The State University of New York

发明人： Kenneth R. Shroyer ,  Luisa F. Escobar-Hoyos ,  Emily I. Chen

IPC分类号： G01N33/574 ,  C12Q1/68

摘要： The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.

公开(公告)号：US20230204583A1

公开(公告)日：2023-06-29

申请号：US18057949

申请日：2022-11-22

申请人： The Research Foundation for The State University of New York

发明人： Kenneth R. Shroyer ,  Luisa F. Escobar-Hoyos ,  Emily I. Chen

IPC分类号： G01N33/574 ,  C12Q1/6886

CPC分类号： G01N33/57411 ,  C12Q1/6886 ,  G01N2333/4742 ,  C12Q2600/158

摘要： The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.