公开(公告)号：US10369158B2

公开(公告)日：2019-08-06

申请号：US15307198

申请日：2015-04-27

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/566 ,  A61K31/57 ,  A61K9/00 ,  A61K45/06

摘要： This invention relates to novel packaged pharmaceutical products for the treatment of neurodegenerative diseases, such as multiple sclerosis, and methods of using these products.

公开(公告)号：US11865122B2

公开(公告)日：2024-01-09

申请号：US17082687

申请日：2020-10-28

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K31/566 ,  A61K49/06

CPC分类号： A61K31/565 ,  A61K31/566 ,  A61K31/57 ,  A61K49/06

摘要： Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.

公开(公告)号：US20210196667A1

公开(公告)日：2021-07-01

申请号：US17203548

申请日：2021-03-16

申请人： The Regents of the University of California

发明人： Michael E. Jung ,  Rhonda R. Voskuhl

IPC分类号： A61K31/277 ,  A61P25/14 ,  A61P25/28 ,  A61P25/16 ,  A61K45/06

摘要： Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-β ligand (ERβ ligand).

公开(公告)号：US20180161346A1

公开(公告)日：2018-06-14

申请号：US15685156

申请日：2017-08-24

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/57 ,  A61K31/565

CPC分类号： A61K31/57 ,  A61K31/565

摘要： The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these Th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post-partum period.

公开(公告)号：US10758496B2

公开(公告)日：2020-09-01

申请号：US15507881

申请日：2015-09-01

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/05 ,  C07D307/93 ,  C07D487/04 ,  C07D307/82 ,  A61K31/137 ,  A61K31/225 ,  C07C39/42 ,  A61K38/13 ,  A61K38/21 ,  A61K45/06

摘要： The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ERβ) ligand.

公开(公告)号：US20170290845A1

公开(公告)日：2017-10-12

申请号：US15507863

申请日：2015-09-01

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K49/06 ,  A61K31/566

摘要： Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.

公开(公告)号：US20170049785A1

公开(公告)日：2017-02-23

申请号：US15307180

申请日：2015-04-27

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/566 ,  A61K31/57

摘要： Provided are methods for treating multiple sclerosis using a continuous regimen of estrogen in combination with periodic administration of a progestogen.

摘要翻译： 提供了使用连续的雌激素方案治疗多发性硬化的方法，并结合定期给予孕激素。

公开(公告)号：US09168262B2

公开(公告)日：2015-10-27

申请号：US13763814

申请日：2013-02-11

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/57 ,  A61K31/573 ,  A61K45/06

CPC分类号： A61K31/565 ,  A61K9/0053 ,  A61K31/56 ,  A61K31/57 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (MS), rheumatoid arthritis (RA), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis.

公开(公告)号：US11622954B2

公开(公告)日：2023-04-11

申请号：US17203548

申请日：2021-03-16

申请人： The Regents of the University of California

发明人： Michael E. Jung ,  Rhonda R. Voskuhl

IPC分类号： C07C255/36 ,  A61K31/277 ,  A61P25/14 ,  A61P25/28 ,  A61P25/16 ,  A61K45/06

摘要： Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-β ligand (ERβ ligand).

公开(公告)号：US20210213033A1

公开(公告)日：2021-07-15

申请号：US17082687

申请日：2020-10-28

申请人： The Regents of the University of California

发明人： Rhonda R. Voskuhl

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K31/566 ,  A61K49/06

摘要： Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.