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公开(公告)号：US09730958B2
公开(公告)日：2017-08-15
申请号：US14627470
申请日：2015-02-20
Applicant: The General Hospital Corporation
IPC: A61B17/20 , A61M35/00 , A61K33/24 , A61M1/08 , A61Q19/10 , A61M37/00 , A61Q19/00 , A61K8/19 , A61B18/04 , A61K9/00 , A61K9/16 , A61K41/00 , A61M1/00 , A61N5/06
CPC classification number: A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
Abstract: The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.
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2.发明申请公开(公告)号：US20170027983A1
公开(公告)日：2017-02-02
申请号：US15290221
申请日：2016-10-11
Applicant: The General Hospital Corporation
CPC classification number: A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
Abstract: One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.
Abstract translation: 本发明的一个方面提供了减轻痤疮的方法，包括：将治疗物质施用于具有滤泡的皮肤区域，所述治疗物质在载体内包含多个金属纳米粒子; 使用装置赋予机械能量以将一些所述治疗物质递送到多个卵泡中; 去除残留在皮肤表面上的组合物，同时将治疗物质留在所述滤泡中; 并用有效治疗痤疮的光能照射施用组合物的皮肤。
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Patent Agency Ranking
公开(公告)号：US10449218B2
公开(公告)日：2019-10-22
申请号：US15648067
申请日：2017-07-12
Applicant: The General Hospital Corporation
IPC: A61B17/20 , A61M35/00 , A61K33/24 , A61M1/08 , A61Q19/00 , A61K8/19 , A61Q19/10 , A61M37/00 , A61B18/04 , A61K9/00 , A61K9/16 , A61K41/00 , A61M1/00 , A61N5/06
Abstract: One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the composition is applied; means to selectively remove at least some of the composition from the skin surface after application of the means to vibrate, while leaving the metallic nanoparticles in proximity to or within the sebaceous gland; and means to optically irradiate the skin to which the composition was applied with light energy after removal of at least some of the composition from the skin surface.
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公开(公告)号：US09687508B2
公开(公告)日：2017-06-27
申请号：US15290221
申请日：2016-10-11
Applicant: The General Hospital Corporation
IPC: A61B17/20 , A61M35/00 , A61K33/24 , A61M1/08 , A61Q19/10 , A61M37/00 , A61Q19/00 , A61K8/19 , A61B18/04 , A61K9/00 , A61K9/16 , A61K41/00 , A61M1/00 , A61N5/06
CPC classification number: A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
Abstract: One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.
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5.发明申请公开(公告)号：US20180353538A1
公开(公告)日：2018-12-13
申请号：US15861343
申请日：2018-01-03
Applicant: The General Hospital Corporation
Inventor： Dilip Paithankar , Richard Dean Blomgren , Richard Rox Anderson , William A. Farinelli , Apostolos G. Doukas , Gerard van Hamel Platerink
CPC classification number: A61K33/24 , A61K9/0009 , A61K9/0014 , A61K9/50 , A61K9/5115 , A61K41/0047
Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
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公开(公告)号：US20170312314A1
公开(公告)日：2017-11-02
申请号：US15648067
申请日：2017-07-12
Applicant: The General Hospital Corporation
IPC: A61K33/24 , A61B18/04 , A61Q19/00 , A61K8/19 , A61K9/00 , A61K9/16 , A61K41/00 , A61M1/08 , A61M35/00 , A61M37/00 , A61Q19/10 , A61M1/00 , A61N5/06
CPC classification number: A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
Abstract: One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the composition is applied; means to selectively remove at least some of the composition from the skin surface after application of the means to vibrate, while leaving the metallic nanoparticles in proximity to or within the sebaceous gland; and means to optically irradiate the skin to which the composition was applied with light energy after removal of at least some of the composition from the skin surface.
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7.发明申请COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING COMPOUNDS FOR FOLLICULAR DELIVERY 审中-公开包含能量吸收化合物的组合物和方法用于快速递送公开(公告)号：US20160310527A1
公开(公告)日：2016-10-27
申请号：US14951444
申请日：2015-11-24
Applicant: The General Hospital Corporation
Inventor： Dilip Paithankar , Richard Dean Blomgren , Richard Rox Anderson , William A. Farinelli , Apostolos G. Doukas , Gerard van Hamel Platerink
CPC classification number: A61K33/24 , A61K9/0009 , A61K9/0014 , A61K9/50 , A61K9/5115 , A61K41/0047
Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
Abstract translation: 本发明提供了包含吸收亚微米颗粒的能量（例如光）的组合物（例如，包含二氧化硅核和金壳的纳米颗粒）以及通过局部施用递送这些颗粒的方法。 通过施加机械搅动（例如按摩），在10Hz-20kHz的范围内的声振动，超声波，交替的吸力和压力以及微喷射器来促进这种输送。
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