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    SYSTEMS AND METHODS FOR PREDICTING AROUSAL TO CONSCIOUSNESS DURING GENERAL ANESTHESIA AND SEDATION
    1.
    发明申请
    SYSTEMS AND METHODS FOR PREDICTING AROUSAL TO CONSCIOUSNESS DURING GENERAL ANESTHESIA AND SEDATION 审中-公开

    公开(公告)号：US20200046229A1

    公开(公告)日：2020-02-13

    申请号：US16657194

    申请日：2019-10-18

    Applicant: The General Hospital Corporation

    Inventor： Patrick L. Purdon ,  Oluwaeseun Akeju ,  Emery N. Brown

    IPC: A61B5/0205 ,  A61B5/00 ,  G06K9/00 ,  A61B5/048 ,  A61B5/0476

    Abstract: A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.

    SYSTEM AND METHOD FOR CHARACTERIZING BRAIN STATES DURING GENERAL ANESTHESIA AND SEDATION USING PHASE-AMPLITUDE MODULATION
    9.
    发明申请
    SYSTEM AND METHOD FOR CHARACTERIZING BRAIN STATES DURING GENERAL ANESTHESIA AND SEDATION USING PHASE-AMPLITUDE MODULATION 审中-公开
    用于通过相位振幅调制在一般麻醉和放血期间表征脑状态的系统和方法

    公开(公告)号：US20160331307A1

    公开(公告)日：2016-11-17

    申请号：US15111002

    申请日：2015-01-14

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： Patrick L. Purdon ,  Eran A. Mukamel ,  Emery N. Brown

    IPC: A61B5/00 ,  A61B5/0478 ,  A61B5/04 ,  A61B5/048

    CPC classification number: A61B5/4821 ,  A61B5/04015 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/4839 ,  A61B5/7246 ,  A61B5/742

    Abstract: A system and method for monitoring and/or controlling a state of consciousness of a subject experiencing anesthesia are provided. In some aspects, the system includes a plurality of sensors placed about the subject and configured to acquire electroencephalogram (“EEG”} data therefrom while the subject is receiving anesthesia, and at least one processor configured to receive the EEG data from the plurality of sensors, and perform a phase-amplitude coupling analysis using the received EEG data to determine a phase-amplitude frequency distribution. The at least one processor is also configured to identify a state of consciousness of the subject using the determined phase-amplitude frequency distribution, and generate a report indicative of the state of consciousness of the subject.

    Abstract translation: 提供了一种用于监测和/或控制经历麻醉的受试者的意识状态的系统和方法。 在一些方面，所述系统包括围绕所述对象放置的多个传感器，并被配置为在所述对象正在接收麻醉时从其获取脑电图（“EEG”），以及配置成从所述多个传感器接收所述EEG数据的至少一个处理器 并且使用所接收的EEG数据执行相位幅度耦合分析以确定相位幅度频率分布，所述至少一个处理器还被配置为使用所确定的相位幅度频率分布来识别所述对象的意识状态，以及 产生一个指示主体意识状态的报告。

    Reversal of General Anesthesia by Administration of Methylphenidate, Amphetamine, Modafinil, Amantadine, and/or Caffeine
    10.
    发明申请
    Reversal of General Anesthesia by Administration of Methylphenidate, Amphetamine, Modafinil, Amantadine, and/or Caffeine 审中-公开
    通过施用哌醋甲酯，安非他明，莫达非尼，金刚烷胺和/或咖啡因来逆转一般麻醉

    公开(公告)号：US20150196249A1

    公开(公告)日：2015-07-16

    申请号：US14618978

    申请日：2015-02-10

    Applicant: The General Hospital Corporation

    Inventor： Emery N. Brown ,  Patrick L. Purdon

    IPC: A61B5/00 ,  A61B5/04 ,  A61B5/0476

    CPC classification number: A61B5/4821 ,  A61B5/04012 ,  A61B5/0476 ,  A61K9/0019 ,  A61K31/13 ,  A61K31/137 ,  A61K31/165 ,  A61K31/4458 ,  A61K31/522 ,  A61K45/06

    Abstract: The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

    Abstract translation: 本发明一般涉及包含促进或增加唤醒时间或逆转全身麻醉引起的无意识的影响的麻醉逆转剂的组合物。 在一些实施方案中，麻醉反转剂可以选自哌甲酯（MPH），苯丙胺，莫达非尼，金刚烷胺，咖啡因或其类似物或衍生物的任何或其组合。 在一些实施方案中，包含至少一种或多种麻醉逆转剂的组合物可用于促进从麻醉中醒来而不出现或减少del妄发生，并且可用于治疗或预防与出现del妄有关的症状的方法，以及 治疗一般患有一般感觉的受试者。 本发明还涉及向受试者和使用者施用包含麻醉逆转剂的这些组合物的方法。

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