公开(公告)号：US20240173208A1

公开(公告)日：2024-05-30

申请号：US18215733

申请日：2023-06-28

申请人： TearClear Corp.

发明人： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC分类号： A61J1/14 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/26 ,  B01J20/28 ,  A61F9/00

CPC分类号： A61J1/1456 ,  A61J1/1468 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  A61F9/0008 ,  B01J2220/52 ,  B01J2220/56

摘要： A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20200346186A1

公开(公告)日：2020-11-05

申请号：US16862918

申请日：2020-04-30

申请人： TearClear Corp.

发明人： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC分类号： B01J20/26 ,  B01J20/28 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/382 ,  A61K31/517

摘要： A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20190307641A1

公开(公告)日：2019-10-10

申请号：US16376387

申请日：2019-04-05

申请人： TearClear Corp. ,  University of Florida Research Foundation, Incorporated

发明人： Howard L. GOLUB ,  Anuj CHAUHAN ,  Michael WILLIAMS

IPC分类号： A61J1/14 ,  A61F9/00 ,  B65D47/06 ,  B65D25/42 ,  B05B1/14 ,  B05B1/34 ,  B65D41/20 ,  B65D35/28

摘要： The present disclosure relates to nozzles for removing a preservative from a fluid comprising a therapeutic agent to an eye. More particularly, the nozzles disclosed herein may minimize patient exposure to preservative by rapidly and selectively removing a preservative from a solution comprising a therapeutic agent. An example nozzle may comprise a flow diverter which directs a flow path from a fluid inlet to a fluid outlet over a length longer than the distance from the inlet to the outlet. In some cases, the nozzle may comprise a preservative removing agent.

公开(公告)号：US20220409430A1

公开(公告)日：2022-12-29

申请号：US17902652

申请日：2022-09-02

申请人： TearClear Corp.

发明人： Michael T. MALANGA ,  Michael WILLIAMS ,  Srini VENKATESH

IPC分类号： A61F9/00 ,  A61K31/222 ,  B01J20/26 ,  B01J20/28 ,  A61K47/18 ,  A61K31/498

摘要： A system comprising a preservative-removing polymeric matrix comprising an active matrix component and an inactive matrix component. A method for administering an ophthalmic agent comprises providing a solution, emulsion, or suspension comprising an ophthalmic agent, and a preservative; and providing a preservative-removing polymeric matrix comprising an active matrix component and an inactive matrix component, and wherein the polymeric matrix is configured to selectively absorb the preservative when the solution, emulsion, or suspension is passed therethrough.

公开(公告)号：US20210267846A1

公开(公告)日：2021-09-02

申请号：US17326081

申请日：2021-05-20

申请人： TearClear Corp. ,  University of Florida Research Foundation, Incorporated

发明人： Howard L. GOLUB ,  Anuj CHAUHAN ,  Michael WILLIAMS

IPC分类号： A61J1/14 ,  A61F9/00 ,  B65D47/06 ,  B65D25/42 ,  B05B1/34 ,  B65D41/20 ,  B65D35/28 ,  B05B1/14

摘要： The present disclosure relates to nozzles for removing a preservative from a fluid comprising a therapeutic agent to an eye. More particularly, the nozzles disclosed herein may minimize patient exposure to preservative by rapidly and selectively removing a preservative from a solution comprising a therapeutic agent. An example nozzle may comprise a flow diverter which directs a flow path from a fluid inlet to a fluid outlet over a length longer than the distance from the inlet to the outlet. In some cases, the nozzle may comprise a preservative removing agent.

公开(公告)号：US20200345583A1

公开(公告)日：2020-11-05

申请号：US16932623

申请日：2020-07-17

申请人： TearClear Corp.

发明人： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC分类号： A61J1/14 ,  A61K31/5377 ,  A61K31/4985 ,  B01D71/26

摘要： A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.