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公开(公告)号：US20130237478A1
公开(公告)日：2013-09-12
申请号：US13855371
申请日：2013-04-02
发明人： Richard Franklin
IPC分类号： A61K38/08 , A61K31/4178 , A61K45/06
CPC分类号： A61K38/085 , A61K31/4178 , A61K38/22 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of peripheral vascular disease (PVD). In particular, the invention provides compositions and methods for treatment of critical limb ischemia, and related diseases, disorders or conditions, based on the use of angiotensin-(1-7) peptides or functional equivalents, analogs or derivatives, angiotensin-(1-7) receptor agonists, ACE2 and/or ACE2 activators.
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公开(公告)号：US20180050079A1
公开(公告)日：2018-02-22
申请号：US15478040
申请日：2017-04-03
发明人： Richard Franklin
IPC分类号： A61K38/08 , A61K45/06 , A61K31/4178
CPC分类号： A61K38/085 , A61K31/4178 , A61K45/06 , A61K47/60 , A61K47/64 , A61K2300/00
摘要： The present invention provides, among other things, methods of treating Marfan Syndrome and/or a Marfan-related disorder including administering to a subject suffering from or susceptible to Marfan Syndrome and/or a Marfan-related disorder an angiotensin (1-7) peptide. In some embodiments, the angiotensin (1-7) peptide is administered at an effective dose periodically at an administration interval such that at least one symptom or feature of Marfan Syndrome and/or a Marfan-related disorder is reduced in intensity, severity, duration, or frequency or has delayed in onset.
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公开(公告)号：US20140094497A1
公开(公告)日：2014-04-03
申请号：US13897051
申请日：2013-05-17
发明人： Richard Franklin
IPC分类号： A61K31/4178
CPC分类号： A61K31/4178 , A61K38/085 , C07K7/14
摘要： The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiotensin (1-7) peptide via either an intravenous or subcutaneous route of administration.
摘要翻译： 本发明尤其提供了用于治疗脑部病症的方法和组合物。 在一些实施方案中，所述方法包括通过静脉内或皮下给药途径向患有脑部病症的受试者施用血管紧张素（1-7）肽。
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公开(公告)号：US08557958B1
公开(公告)日：2013-10-15
申请号：US13757475
申请日：2013-02-01
发明人： Richard Franklin
CPC分类号： A61K31/4178 , A61K38/085 , A61K45/06 , C07K7/14 , A61K2300/00
摘要： The present invention relates to compositions and methods for treatment and/or prevention of diabetes or pre-diabetes. In particular, the invention provides compositions and methods for the treatment and/or prevention of diabetes or pre-diabetes, based on the use of angiotensin-(1-7) peptides, functional equivalents thereof, and/or angiotensin (1-7) agonists.
摘要翻译： 本发明涉及治疗和/或预防糖尿病或前期糖尿病的组合物和方法。 特别地，基于使用血管紧张素（1-7）肽，其功能等同物和/或血管紧张素（1-7）），本发明提供了治疗和/或预防糖尿病或前期糖尿病的组合物和方法， 激动剂。
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公开(公告)号：US20170275333A1
公开(公告)日：2017-09-28
申请号：US14817735
申请日：2015-08-04
发明人： Richard Franklin
摘要： The present invention provides, among other things, novel peptides and compositions for treating disease.
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公开(公告)号：US09333233B2
公开(公告)日：2016-05-10
申请号：US14549096
申请日：2014-11-20
发明人： Richard Franklin
IPC分类号： A61K38/08
CPC分类号： A61K38/085
摘要： The present invention provides, among other things, method of treating stroke including a step of administering an angiotensin (1-7) peptide to a subject suffering from a stroke, approximately 24 hours after the stroke. In some embodiments, treatment begins more than 24 hours after the stroke. In some embodiments, administration of an angiotensin (1-7) peptide results in a reduction in the intensity, severity, duration, and/or frequency of at least one symptom or feature of the one or more complications of stroke.
摘要翻译： 本发明尤其提供了治疗中风的方法，包括在中风后约24小时向患有卒中的受试者施用血管紧张素（1-7）肽的步骤。 在一些实施方案中，治疗在卒中后超过24小时开始。 在一些实施方案中，施用血管紧张素（1-7）肽导致中风的一种或多种并发症的至少一种症状或特征的强度，严重程度，持续时间和/或频率的降低。
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公开(公告)号：US20150105335A1
公开(公告)日：2015-04-16
申请号：US14506497
申请日：2014-10-03
发明人： Richard Franklin
摘要： The present invention provides, among other things, novel peptides and compositions for treating disease.
摘要翻译： 本发明尤其提供用于治疗疾病的新型肽和组合物。
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公开(公告)号：US20150057216A1
公开(公告)日：2015-02-26
申请号：US14365565
申请日：2012-12-14
发明人： Paul Beringer , Richard Franklin
IPC分类号： A61K38/08
CPC分类号： A61K38/085 , A61K31/4178
摘要： The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on Angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided.
摘要翻译： 本发明尤其提供了用于治疗或预防基于血管紧张素（1-7）多肽的纤维化疾病，病症或病症及其类似物或衍生物的方法和组合物。 在一些实施方案中，用于治疗或预防肺纤维化，肺动脉高压，慢性阻塞性肺病（COPD），哮喘，囊性纤维化，肾纤维化，肝纤维化，系统性硬化，手术后粘连，加速伤口愈合以及减少的组合物和方法 或防止瘢痕形成。
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公开(公告)号：US20190000809A1
公开(公告)日：2019-01-03
申请号：US15870233
申请日：2018-01-12
发明人： Richard Franklin
IPC分类号： A61K31/4178 , A61K38/08 , C07K7/14
摘要： The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiotensin (1-7) peptide via either an intravenous or subcutaneous route of administration.
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公开(公告)号：US09511055B2
公开(公告)日：2016-12-06
申请号：US13897051
申请日：2013-05-17
发明人： Richard Franklin
IPC分类号： C07K7/14 , A61K31/4178 , A61K38/08
CPC分类号： A61K31/4178 , A61K38/085 , C07K7/14
摘要： The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiotensin (1-7) peptide via either an intravenous or subcutaneous route of administration.
摘要翻译： 本发明尤其提供了用于治疗脑部病症的方法和组合物。 在一些实施方案中，所述方法包括通过静脉内或皮下给药途径向患有脑部病症的受试者施用血管紧张素（1-7）肽。
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