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公开(公告)号：US09532974B2
公开(公告)日：2017-01-03
申请号：US14837023
申请日：2015-08-27
申请人： Targacept, Inc.
发明人： Srinivasa Rao Akireddy , Balwinder Singh Bhatti , Ronald Joseph Heemstra , Matt S. Melvin , Jason Speake , Yunde Xiao , Daniel Yohannes
IPC分类号： A61K31/13 , A61K31/40 , C07C211/38 , C07C211/41 , C07D205/04 , C07D295/033 , A61K31/397
CPC分类号： A61K31/13 , A61K31/397 , A61K31/40 , C07C211/38 , C07C211/41 , C07D205/04 , C07D295/033
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
摘要翻译： 本发明涉及将烟碱受体调节为非竞争性拮抗剂的化合物，其合成方法，使用方法及其药物组合物。
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公开(公告)号：US20140288185A1
公开(公告)日：2014-09-25
申请号：US14355316
申请日：2012-11-01
申请人： Targacept, Inc.
发明人： Srinivasa Rao Akireddy , Jason Speake , Balwinder Singh Bhatti , Daniel Yohannes , John Genus , Yunde Xiao
IPC分类号： C07C211/38 , C07C215/42
CPC分类号： C07C211/38 , C07C215/42 , C07C215/44
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
摘要翻译： 本发明涉及将烟碱受体调节为非竞争性拮抗剂的化合物，其合成方法，使用方法及其药物组合物。
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公开(公告)号：US20140315877A1
公开(公告)日：2014-10-23
申请号：US14320782
申请日：2014-07-01
申请人： Targacept, Inc.
发明人： Srinivasa Rao Akireddy , Balwinder Singh Bhatti , Ronald Joseph Heemstra , Matt S. Melvin , Jason Speake , Yunde Xiao , Daniel Yohannes
IPC分类号： C07C211/38 , C07D205/04 , C07D295/033
CPC分类号： A61K31/13 , A61K31/397 , A61K31/40 , C07C211/38 , C07C211/41 , C07D205/04 , C07D295/033
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
摘要翻译： 本发明涉及将烟碱受体调节为非竞争性拮抗剂的化合物，其合成方法，使用方法及其药物组合物。
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公开(公告)号：US20160008323A1
公开(公告)日：2016-01-14
申请号：US14837023
申请日：2015-08-27
申请人： Targacept, Inc.
发明人： Srinivasa Rao Akireddy , Balwinder Singh Bhatti , Ronald Joseph Heemstra , Matt S. Melvin , Jason Speake , Yunde Xiao , Daniel Yohannes
IPC分类号： A61K31/40 , A61K31/397 , A61K31/13
CPC分类号： A61K31/13 , A61K31/397 , A61K31/40 , C07C211/38 , C07C211/41 , C07D205/04 , C07D295/033
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
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![PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S, 3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE](/abs-image/US/2014/06/12/US20140163065A1/abs.jpg.150x150.jpg)
5.发明申请PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S, 3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE 有权（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-亚甲基] [2.2.2] OCT-3-YL）-3,5-二氟硼酰胺的制备和治疗应用公开(公告)号：US20140163065A1
公开(公告)日：2014-06-12
申请号：US13893382
申请日：2013-05-14
申请人： TARGACEPT, INC.
发明人： Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
IPC分类号： A61K31/444
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。
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![Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide](/abs-image/US/2015/11/03/US09173876B2/abs.jpg.150x150.jpg)
6.发明授权Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide 有权（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用公开(公告)号：US09173876B2
公开(公告)日：2015-11-03
申请号：US14518049
申请日：2014-10-20
申请人： Targacept, Inc.
发明人： Merouane Bencherif , Nikolai Federov , Terry Hauser , Kristen G. Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
IPC分类号： A61K31/439 , A61K31/444 , C07D453/02
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。
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![PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE](/abs-image/US/2015/04/16/US20150105421A1/abs.jpg.150x150.jpg)
7.发明申请PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE 有权（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-亚甲基] [2.2.2] OCT-3-YL）-3,5-二氟硼酰胺的制备和治疗应用公开(公告)号：US20150105421A1
公开(公告)日：2015-04-16
申请号：US14518049
申请日：2014-10-20
申请人： Targacept, Inc.
发明人： Merouane Bencherif , Nikolai Federov , Terry Hauser , Kristen G. Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
IPC分类号： A61K31/444
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。
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![Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide](/abs-image/US/2014/12/02/US08901151B2/abs.jpg.150x150.jpg)
8.发明授权Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide 有权（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2] OCT-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用公开(公告)号：US08901151B2
公开(公告)日：2014-12-02
申请号：US13893382
申请日：2013-05-14
申请人： Targacept, Inc.
发明人： Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
IPC分类号： A61K31/44
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。
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