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35 条记录 (耗时 0.054 秒)

    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    5.
    发明申请
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US20040176348A1

    公开(公告)日：2004-09-09

    申请号：US10379868

    申请日：2003-03-05

    申请人： Aventis Pharma S.A. ,  Targacept, Inc.

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC分类号： A61K031/513 ,  A61K031/506 ,  C07D43/02

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF
    7.
    发明申请
    ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF 审中-公开
    阿维林霉素化合物及其制备和使用方法

    公开(公告)号：US20140107164A1

    公开(公告)日：2014-04-17

    申请号：US14108918

    申请日：2013-12-17

    申请人： Targacept, Inc.

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve ,  Craig Harrison Miller

    IPC分类号： C07D405/14

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    CHEMICAL ENTITY SEARCH, FOR A COLLABORATION AND CONTENT MANAGEMENT SYSTEM
    9.
    发明申请
    CHEMICAL ENTITY SEARCH, FOR A COLLABORATION AND CONTENT MANAGEMENT SYSTEM 审中-公开
    化学实体搜索，用于协作和内容管理系统

    公开(公告)号：US20130308840A1

    公开(公告)日：2013-11-21

    申请号：US13867432

    申请日：2013-04-22

    申请人： Targacept, Inc.

    发明人： Kartik Tallapragada ,  Joseph Chewning ,  David Kombo ,  Beverly Ludwick

    IPC分类号： G06F17/30

    CPC分类号： G06F16/5846 ,  G16C20/70 ,  G16C20/90

    摘要： A method of obtaining chemical or molecular compound information from a document is provided. The method includes applying optical structure recognition to a document and extracting compound structure information from data obtained by applying the optical structure recognition. The method includes applying a text search module to a main body of the document and metadata of the document and extracting one or more chemical names from data obtained by applying the text search module to the main body and to the metadata. The method includes storing, in a database, an identifier, the compound structure information, and the one or more chemical names, wherein at least one method operation is executed through a processor.

    摘要翻译： 提供了从文件获得化学或分子化合物信息的方法。 该方法包括对文档应用光学结构识别，并通过应用光学结构识别获得的数据提取复合结构信息。 该方法包括将文本搜索模块应用于文档的主体和文档的元数据，并从通过将文本搜索模块应用于主体和元数据而获得的数据中提取一个或多个化学名称。 该方法包括在数据库中存储标识符，复合结构信息和一个或多个化学名称，其中通过处理器执行至少一个方法操作。

    METHOD OF TREATING BLADDER DISORDERS
    10.
    发明申请
    METHOD OF TREATING BLADDER DISORDERS 有权
    治疗刮板疾病的方法

    公开(公告)号：US20130253067A1

    公开(公告)日：2013-09-26

    申请号：US13798248

    申请日：2013-03-13

    申请人： TARGACEPT, INC.

    发明人： Merouane Bencherif ,  Steven M. Toler

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of bladder disorders, including overactive bladder.

    摘要翻译： 本发明涉及右美沙咪胺和基本上不含外消旋甲卡西林的美沙芬胺在治疗膀胱疾病（包括膀胱活动过度）中的用途。