PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE
    4.
    发明申请
    PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE 有权
    细胞摄取的细胞是可控的

    公开(公告)号:US20120134931A1

    公开(公告)日:2012-05-31

    申请号:US13384591

    申请日:2010-07-15

    摘要: Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

    摘要翻译: 在某些实施方案中,本文公开了具有增加的体内循环的选择性转运分子。 在一些实施方案中,本文公开的选择性转运分子具有式(A-X-B-C)-M,其中C是货物部分; A是具有包含5至9个连续酸性氨基酸的序列的肽,其中所述氨基酸选自:天冬氨酸和谷氨酸; B是具有包含5至20个连续碱性氨基酸的序列的肽; X是一个连接子; M是大分子载体。

    PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE
    5.
    发明申请
    PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE 有权
    细胞摄取的细胞是可控的

    公开(公告)号:US20120134922A1

    公开(公告)日:2012-05-31

    申请号:US13384581

    申请日:2010-07-15

    IPC分类号: A61K51/00 C07K7/02 A61K49/00

    摘要: Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A—X—B—C)n—M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

    摘要翻译: 在某些实施方案中,本文公开了具有增加的体内循环的选择性转运分子。 在一些实施方案中,本文公开的选择性转运分子具有式(A-X-B-C)n-M,其中C是货物部分; A是具有包含5至9个连续酸性氨基酸的序列的肽,其中所述氨基酸选自:天冬氨酸和谷氨酸; B是具有包含5至20个连续碱性氨基酸的序列的肽; X是一个连接子; M是大分子载体。

    Peptides whose uptake by cells is controllable
    7.
    发明授权
    Peptides whose uptake by cells is controllable 有权
    细胞摄取的肽是可控的

    公开(公告)号:US07985401B2

    公开(公告)日:2011-07-26

    申请号:US11133804

    申请日:2005-05-19

    IPC分类号: A61M36/14 A61K51/00

    摘要: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

    摘要翻译: 本发明的肽的一般结构包括A-X-B-C,其中C是货物部分,B部分包括碱性氨基酸,X是可切割的接头序列,A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而,在X的细胞外裂解时,B-C部分被吸收,将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂,化学治疗药物或用于治疗的放射线敏化剂。 X可能在细胞外或细胞内裂解。 本发明的分子可以是直链,环状,支链或具有混合结构。

    Peptides whose uptake by cells is controllable
    8.
    发明申请
    Peptides whose uptake by cells is controllable 有权
    细胞摄取的肽是可控的

    公开(公告)号:US20060041105A1

    公开(公告)日:2006-02-23

    申请号:US11133804

    申请日:2005-05-19

    IPC分类号: A61K38/12

    摘要: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present inventnon may be linear, cyclic, branched, or have a mixed structure.

    摘要翻译: 本发明的肽的一般结构包括A-X-B-C,其中C是货物部分,B部分包括碱性氨基酸,X是可切割的接头序列,A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而,在X的细胞外裂解时,B-C部分被吸收,将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂,化学治疗药物或用于治疗的放射线敏化剂。 X可能在细胞外或细胞内裂解。 本发明的分子可以是直链,环状,支链或具有混合结构。

    Peptides whose uptake by cells is controllable
    9.
    发明申请
    Peptides whose uptake by cells is controllable 有权
    细胞摄取的肽是可控的

    公开(公告)号:US20050107583A1

    公开(公告)日:2005-05-19

    申请号:US10699562

    申请日:2003-10-31

    申请人: Tao Jiang Roger Tsien

    发明人: Tao Jiang Roger Tsien

    摘要: A generic structure for the peptides of the present invention includes A-X—B—C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B—C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

    摘要翻译: 本发明的肽的一般结构包括A-X-B-C,其中C是货物部分,B部分包括碱性氨基酸,X是可切割的接头序列,A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而,在X的细胞外裂解时,B-C部分被吸收,将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂,化学治疗药物或用于治疗的放射线敏化剂。 X的裂解允许A与B分离,揭示B中碱性氨基酸的正常能力,将货物C拖入裂解事件附近的细胞。 X在细胞外裂解,优选在生理条件下。 对于A和B部分,D-氨基酸是优选的,以使由背景肽酶或蛋白酶的免疫原性和非特异性切割最小化。