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公开(公告)号：US20230346897A1
公开(公告)日：2023-11-02
申请号：US17914271
申请日：2021-03-24
Applicant: Talengen International Limited
Inventor： Jinan LI
IPC: A61K38/48 , A61K38/57 , A61K45/06 , A61P25/28 , A61K39/395
CPC classification number: A61K38/484 , A61K38/57 , A61K45/06 , A61P25/28 , A61K39/3955
Abstract: Provided in the present invention is a method for promoting the degradation of a misfolded protein and an aggregate thereof. The method includes administrating a therapeutically effective amount of plasminogen activation pathway components to a subject. Further provided in the present invention are a drug containing the plasminogen activation pathway components, a pharmaceutical composition, a product and a kit, which are used to prevent and treat diseases caused by the misfolded protein and/or the aggregate thereof.
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公开(公告)号：US20220218799A1
公开(公告)日：2022-07-14
申请号：US17595113
申请日：2020-05-11
Applicant: TALENGEN INTERNATIONAL LIMITED
Inventor： Jinan LI
Abstract: Disclosed is a method for treating amyotrophic lateral sclerosis (ALS), including administering a therapeutically effective amount of a plasminogen pathway activator to a subject. Further disclosed are a pharmaceutical composition, a product, and a kit comprising the plasminogen pathway activator, for treating amyotrophic lateral sclerosis.
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公开(公告)号：US20190314463A1
公开(公告)日：2019-10-17
申请号：US16469817
申请日：2017-06-19
Applicant: Talengen International Limited
Inventor： Jinan LI
Abstract: The present invention relates to a method for restoring a balance between glucagon and insulin to normal, comprising administering an effective amount of plasminogen to a subject; furthermore, the present invention relates to a medicament for restoring a balance between glucagon and insulin to normal.
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公开(公告)号：US20190015485A1
公开(公告)日：2019-01-17
申请号：US16062049
申请日：2016-12-16
Applicant: TALENGEN INTERNATIONAL LIMITED
Inventor： Jinan LI
Abstract: The present invention relates to the effect of plasminogen in the prevention and/or treatment of diabetic nephropathy. Compared with other existing drugs for treating diabetic nephropathy, the plasminogen of the present invention has significant effects of improving renal microvascular injury, reducing glomerular basement membrane and glomerular mesangial thickening, and the like.
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公开(公告)号：US20240000903A1
公开(公告)日：2024-01-04
申请号：US18037299
申请日：2021-11-17
Applicant: Talengen International Limited
Inventor： Jinan LI
CPC classification number: A61K38/484 , A61K45/06 , C12Y304/21007
Abstract: The present invention relates to a method for promoting the formation of mature BDNF and increasing the level of BDNF. The method comprises administering a therapeutically effective amount of a plasminogen pathway activator to a subject. The present invention also relates to a pharmaceutical composition, a product and a kit which comprises the plasminogen pathway activator and are used for promoting the formation of mature BDNF and increasing the BDNF level.
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Patent Agency Ranking
公开(公告)号：US20230302102A1
公开(公告)日：2023-09-28
申请号：US18022084
申请日：2021-08-20
Applicant: Talengen International Limited
Inventor： Jinan LI
CPC classification number: A61K38/484 , C12Y304/21007 , A61P35/00
Abstract: The present invention provides a method for treating a tumor in a subject, maintaining or improving body organ function under tumor conditions, and prolonging the survival period of the subject, comprising administering to the subject a prophylactically and/or therapeutically effective amount of components such as plasminogen of a plasminogen activation pathway. The present invention also provides a medicament comprising plasminogen, a pharmaceutical composition, a formulation and a kit for treating a tumor in a subject.
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公开(公告)号：US20230190891A1
公开(公告)日：2023-06-22
申请号：US17924620
申请日：2021-05-11
Applicant: Talengen International Limited
Inventor： Jinan LI
CPC classification number: A61K38/484 , A61P11/00 , A61P21/00 , A61P29/00 , A61P25/00 , A61K9/0019 , A61K9/0073 , C12Y304/21007
Abstract: The present application relates to a method for treating spinal muscular atrophy (SMA), comprising: administering a therapeutically effective amount of a plasminogen pathway activator to a subject. The present application also relates to a pharmaceutical composition, product, and kit comprising said plasminogen pathway activator, which are used for treating spinal muscular atrophy.
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公开(公告)号：US20200085920A1
公开(公告)日：2020-03-19
申请号：US16469618
申请日：2017-06-19
Applicant: Talengen International Limited
Inventor： Jinan LI
Abstract: The present invention relates to a method for preventing and/or treating fatty liver and its related conditions in a subject, comprising administering an effective amount of plasminogen to the subject; in another aspect, the present invention further relates to a medicament, a pharmaceutical composition, an article of manufacture, and a kit comprising plasminogen which are useful for preventing and/or treating fatty liver and its related conditions in the subject.
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公开(公告)号：US20190328848A1
公开(公告)日：2019-10-31
申请号：US16469960
申请日：2017-06-19
Applicant: TALENGEN INTERNATIONAL LIMITED
Inventor： Jinan LI
IPC: A61K38/48 , A61K33/243 , A61P13/12
Abstract: The present invention relates to a method for preventing and/or treating a drug-induced renal tissue injury and its related conditions in a subject, comprising administering an effective amount of plasminogen to the subject. The present invention further relates to a medicament, a pharmaceutical composition, an article of manufacture, and a kit comprising plasminogen which are useful for preventing and/or treating a drug-induced renal tissue injury and its related conditions in a subject.
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公开(公告)号：US20190151422A1
公开(公告)日：2019-05-23
申请号：US16062410
申请日：2016-12-16
Applicant: Talengen International Limited
Inventor： Jinan LI
Abstract: The present invention relates to the use of plasminogen in the treatment of cervical erosion. Compared to other existing drugs for treating cervical erosion, the plasminogen or plasmin of the present invention can promote the inflammatory repair of damaged mucosa. Therefore, plasminogen may become a novel strategy to treat cervical erosion.
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