公开(公告)号：US20170202777A1

公开(公告)日：2017-07-20

申请号：US15245815

申请日：2016-08-24

申请人： Takeda Pharmaceutical Company Limited

发明人： Wataru Hoshina ,  Masafumi Misaki

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K31/4188

CPC分类号： A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/28 ,  A61K31/4188 ,  A61K47/02

摘要： The present invention provides a solid preparation wherein variation in weight is suppressed, a solid preparation wherein the active ingredient is stabilized, and a stabilization method thereof. A solid preparation containing (1) an active ingredient, (2) D-mannitol and (3) an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate. A method of stabilizing the active ingredient, including adding an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate.

公开(公告)号：US10350170B2

公开(公告)日：2019-07-16

申请号：US15553852

申请日：2016-02-25

申请人： Takeda Pharmaceutical Company Limited

发明人： Ikuro Yamane ,  Yukihiro Nomura ,  Yutaka Nishimoto ,  Wataru Hoshina

IPC分类号： A61K9/36 ,  A61K9/20 ,  A61K31/519 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K9/28

摘要： Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.

公开(公告)号：US20190054026A1

公开(公告)日：2019-02-21

申请号：US15926373

申请日：2018-03-20

申请人： Takeda Pharmaceutical Company Limited

发明人： Wataru Hoshina ,  Masafumi Misaki

IPC分类号： A61K9/20 ,  A61K31/4188 ,  A61K47/02 ,  A61K9/28

摘要： The present invention provides a solid preparation wherein variation in weight is suppressed, a solid preparation wherein the active ingredient is stabilized, and a stabilization method thereof. A solid preparation containing (1) an active ingredient, (2) D-mannitol and (3) an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate. A method of stabilizing the active ingredient, including adding an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate.