公开(公告)号：US20210269420A1

公开(公告)日：2021-09-02

申请号：US17256330

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Kentaro RIKIMARU ,  Yoshihiro BANNO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Yoshihide TOMATA ,  Yuji ISHICHI ,  Shogo MARUI ,  Tsuneo ODA ,  Tohru MIYAZAKI ,  Yasutaka HOASHI ,  Yasushi HATTORI ,  Yuichi KAJITA ,  Yuhei MIYANOHANA ,  Tatsuki KOIKE

IPC: C07D401/14 ,  C07D405/14 ,  C07D211/56

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US20220081399A1

公开(公告)日：2022-03-17

申请号：US17154712

申请日：2021-01-21

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Kentaro RIKIMARU ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Mariko HIROZANE

IPC: C07D211/24 ,  C07D215/44 ,  C07D211/36 ,  C07D211/56 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  A61P25/00

Abstract: Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.

公开(公告)号：US20190031611A1

公开(公告)日：2019-01-31

申请号：US16075240

申请日：2017-02-01

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Kentaro RIKIMARU ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Mariko HIROZANE

IPC: C07D211/36 ,  A61P25/00

Abstract: Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.

公开(公告)号：US20240174610A1

公开(公告)日：2024-05-30

申请号：US18347345

申请日：2023-07-05

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Kentaro RIKIMARU ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Mariko HIROZANE

IPC: C07D211/24 ,  A61P25/00 ,  C07D211/36 ,  C07D211/56 ,  C07D215/44 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

CPC classification number: C07D211/24 ,  A61P25/00 ,  C07D211/36 ,  C07D211/56 ,  C07D215/44 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I):






wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.

公开(公告)号：US20190263843A1

公开(公告)日：2019-08-29

申请号：US16410463

申请日：2019-05-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko Fujimoto ,  Kentaro RIKIMARU ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Mariko HIROZANE

IPC: C07F7/18 ,  C07D405/06 ,  C07D417/06 ,  C07D413/06 ,  C07D409/12 ,  C07D409/06 ,  C07D405/14 ,  C07D211/24 ,  C07D417/14 ,  C07D401/14 ,  C07D401/12 ,  C07D401/06 ,  C07D211/56 ,  C07D405/12

Abstract: Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.