公开(公告)号：US09265970B2

公开(公告)日：2016-02-23

申请号：US13393418

申请日：2011-03-02

Applicant: Taizo Honda ,  Masahiro Ikeda

Inventor： Taizo Honda ,  Masahiro Ikeda

IPC: H01J3/26 ,  A61N5/10

CPC classification number: A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: A particle beam irradiation system comprises deflection electromagnets which scan by deflecting the particle beam in two dimensions in the lateral direction which is perpendicular to an irradiation direction of the particle beam, and an energy width expanding device through which the particle beam passes so as to expand an energy width of the particle beam and form a SOBP in a depth direction of the irradiation target, that is, in an irradiation direction of the particle beam, wherein the energy width expanding device is configured to form the SOBP in the depth direction along whole irradiation area in the depth direction of the irradiation target, and the deflection electromagnets are controlled so as for an irradiation spot which is formed in the irradiation target by the particle beam to move stepwise along whole irradiation area in the lateral direction of the irradiation target.

Abstract translation: 粒子束照射系统包括偏转电磁体，该偏转电磁体通过在与粒子束的照射方向垂直的横向方向上的二维偏转粒子束进行扫描;以及能量扩大装置，粒子束通过该能量扩张装置以扩展 粒子束的能量宽度，并且在照射对象的深度方向，即在粒子束的照射方向上形成SOBP，其中，能量宽度扩展装置被构造成沿着整个深度方向形成SOBP 照射对象的深度方向的照射区域，并且对于通过粒子束形成在照射对象物上的照射点，控制偏转电磁体，沿着照射对象的横向的整个照射区域逐步移动。

公开(公告)号：US08854048B2

公开(公告)日：2014-10-07

申请号：US13262866

申请日：2011-03-10

Applicant: Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

Inventor： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC: G01N27/62 ,  A61N5/10

CPC classification number: H01J37/304 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J47/02

Abstract: In a particle beam therapy system which scans a particle beam and irradiates the particle beam to an irradiation position of an irradiation subject and has a dose monitoring device for measuring a dose of the particle beam and an ionization chamber smaller than the dose monitoring device, the ionization chamber measuring a dose of a particle beam passing through the dose monitoring device, the dose of the particle beam irradiated by the dose monitoring device is measured; the dose of the particle beam passing through the dose monitoring device is measured by the small ionization chamber; and a correction coefficient of the dose measured by the dose monitoring device corresponding to the irradiation position is found based on the dose of the particle beam measured by the small ionization chamber.

Abstract translation: 在粒子束治疗系统中，扫描粒子束并将粒子束照射到照射对象的照射位置，并且具有用于测量粒子束的剂量和小于剂量监测装置的电离室的剂量监测装置， 电离室测量通过剂量监测装置的粒子束的剂量，测量由剂量监测装置照射的粒子束的剂量; 通过小电离室测量通过剂量监测装置的粒子束的剂量; 并且基于由小电离室测量的粒子束的剂量，求出由与照射位置对应的剂量监测装置测量的剂量的校正​​系数。

公开(公告)号：US08421031B2

公开(公告)日：2013-04-16

申请号：US13258772

申请日：2011-03-10

Applicant: Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

Inventor： Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

IPC: H01J3/26 ,  A61N5/10

CPC classification number: A61N5/1043 ,  A61N5/1048 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087

Abstract: The objective is to obtain a particle beam therapy system that can suppress the effect of a leakage dose. There are provided a scanning nozzle that irradiates in a predetermined direction a particle beam emitted from an accelerator; an irradiation control unit that controls operation of the irradiation nozzle in such a way that the particle beam of a predetermined dose is sequentially irradiated onto each of a plurality of spots set in a planar direction in an irradiation subject; and a control unit that on/off-controls emission of the particle beam from the accelerator. The irradiation control unit makes the irradiation nozzle scan in a diluting manner the particle beam onto a predetermined area in the irradiation subject, in a predetermined period after a time point when emission is switched from ON to OFF, or in a period from the time point when emission is switched from ON to OFF to a time point when the particle beam is cut off.

Abstract translation: 目的是获得能够抑制泄漏剂量影响的粒子束治疗系统。 提供了沿预定方向照射从加速器发射的粒子束的扫描喷嘴; 照射控制单元，其以照射对象的平面方向上设置的多个点顺序地照射预定剂量的粒子束的方式控制照射喷嘴的动作; 以及控制单元，其控制来自加速器的粒子束的发射。 照射控制单元使得照射喷嘴在发射从ON切换到OFF之后的预定时间内或在从时间点开始的时间段内，将粒子束以稀释的方式扫描到照射对象的预定区域上 当发射从ON切换到截止到粒子束的时间点时。

公开(公告)号：US20120223247A1

公开(公告)日：2012-09-06

申请号：US13393418

申请日：2011-03-02

Applicant: Taizo Honda ,  Masahiro Ikeda

Inventor： Taizo Honda ,  Masahiro Ikeda

IPC: H01J3/26

CPC classification number: A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: A particle beam irradiation system comprises deflection electromagnets which scan by deflecting the particle beam in two dimensions in the lateral direction which is perpendicular to an irradiation direction of the particle beam, and an energy width expanding device through which the particle beam passes so as to expand an energy width of the particle beam and form a SOBP in a depth direction of the irradiation target, that is, in an irradiation direction of the particle beam, wherein the energy width expanding device is configured to form the SOBP in the depth direction along whole irradiation area in the depth direction of the irradiation target, and the deflection electromagnets are controlled so as for an irradiation spot which is formed in the irradiation target by the particle beam to move stepwise along whole irradiation area in the lateral direction of the irradiation target.

Abstract translation: 粒子束照射系统包括偏转电磁体，该偏转电磁体通过在垂直于粒子束的照射方向的横向方向上的二维偏转粒子束进行扫描;以及能量扩大装置，粒子束通过该能量扩展装置以扩展 粒子束的能量宽度，并且在照射对象的深度方向，即在粒子束的照射方向上形成SOBP，其中，能量宽度扩展装置被构造成沿着整个深度方向形成SOBP 照射对象的深度方向的照射区域，并且对于通过粒子束形成在照射对象物上的照射点，控制偏转电磁体，沿着照射对象的横向的整个照射区域逐步移动。

公开(公告)号：US09101763B2

公开(公告)日：2015-08-11

申请号：US14240650

申请日：2011-11-03

Applicant: Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

Inventor： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC: A61N5/00 ,  A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: A particle beam irradiation apparatus according to the present invention is provided with a vacuum duct that forms a vacuum region through which the charged particle beam passes, a vacuum window through which the charged particle beam is launched from the vacuum region, a scanning electromagnet that scans the charged particle beam; a monitoring apparatus including a position monitor that detects the passing position of a charged particle beam and the beam size thereof, a low-scattering gas filling chamber including the monitoring apparatus, and an irradiation management apparatus that controls irradiation of the charged particle beam; the particle beam irradiation apparatus is characterized in that the low-scattering gas filling chamber is changeably disposed in such a manner that the beam-axis-direction positional relationship between the monitoring apparatus and the vacuum window is a desired one and in that the low-scattering gas filling chamber is filled with a low-scattering gas.

Abstract translation: 根据本发明的粒子束照射装置设置有真空管道，该真空管道形成带电粒子束通过的真空区域，从真空区域发射带电粒子束的真空窗口，扫描的扫描电磁体 带电粒子束; 监视装置，其包括检测带电粒子束的通过位置的位置监视器及其光束尺寸，包括监视装置的低散射气体填充室以及控制带电粒子束的照射的照射管理装置; 所述粒子束照射装置的特征在于，所述低散射气体充填室可变地设置成使得所述监视装置和所述真空窗口之间的射束轴向位置关系是期望的， 散射气体填充室填充有低散射气体。

公开(公告)号：US09079026B2

公开(公告)日：2015-07-14

申请号：US14386626

申请日：2012-03-21

Applicant: Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

Inventor： Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

IPC: A61N5/10

CPC classification number: A61N5/1071 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087

Abstract: A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value.

Abstract translation: 粒子束扫描照射方法包括以下步骤：基于粒子束照射的相对量和从粒子束确定的处方粒子束剂量来计算每个照射点的粒子束的计划照射粒子数 治疗方案; 基于所计划的照射粒子数和粒子束的束电流波形，模拟在各照射点处的粒子束的照射过程，计算在扫描位移期间照射患病部位的粒子束的粒子数 粒子束; 通过使用扫描偏移期间的照射粒子数来校正每个照射点的计划照射粒子数; 将校正的计划照射粒子数转换为剂量监视器中使用的计数值; 并且基于转换后的计数值，用粒子束照射照射点。

公开(公告)号：US09067065B2

公开(公告)日：2015-06-30

申请号：US13977058

申请日：2011-03-07

Applicant: Yukiko Yamada ,  Hisashi Harada ,  Takaaki Iwata ,  Toshihiro Otani ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

Inventor： Yukiko Yamada ,  Hisashi Harada ,  Takaaki Iwata ,  Toshihiro Otani ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC: A61N5/10 ,  G21K1/093

CPC classification number: A61N5/1048 ,  A61N5/1043 ,  A61N5/1075 ,  A61N2005/1087 ,  G21K1/093

Abstract: The particle beam irradiation apparatus comprises: a position monitor that detects a passing position of a charged particle beam; and an irradiation control apparatus that calculates a distance from a predetermined reference point to the position monitor, calculates a beam irradiation position on an irradiation subject, and controls irradiation of the beam; wherein the irradiation control apparatus includes a position calculation apparatus that calculates the beam irradiation position, based on a beam position detected by the position monitor, a scanning starting point distance information on a distance from a irradiation plane of the irradiation subject to a scanning starting point, of the beam, in a scanning electromagnet, and a position monitor distance information on a distance, from the irradiation plane to the position monitor, that is calculated based on the calculated distance.

Abstract translation: 粒子束照射装置包括：位置监视器，其检测带电粒子束的通过位置; 以及照射控制装置，其计算从预定基准点到所述位置监视器的距离，计算照射对象的光束照射位置，并控制所述光束的照射; 其特征在于，所述照射控制装置包括：位置计算装置，其基于由所述位置监视器检测到的光束位置计算所述光束照射位置;从所述照射对象的照射面到扫描开始点的距离的扫描开始点距离信息 ，扫描电磁体中的距离信息，以及从照射平面到位置监视器的基于计算出的距离计算的位置监视距离信息。

公开(公告)号：US20140323793A1

公开(公告)日：2014-10-30

申请号：US14356629

申请日：2012-03-27

Applicant: Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

Inventor： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

IPC: A61N5/10

CPC classification number: A61N5/1048 ,  A61N5/1043 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H13/04 ,  H05H2277/11

Abstract: A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition.

Abstract translation: 控制单元设置有保持部，其保持多个操作模式，每个操作模式是由加速器周期性重复的操作模式，所述操作模式具有针对粒子束的不同发射次数调整的各自的操作条件，以使得 加速器中的偏转电磁体即使在滞后的情况下也具有预期的磁场强度; 用于读取每个切片的照射条件的用于在深度方向上的照射目标的多个切片的读取部分; 选择部，其基于读取的照射条件选择适合于每个切片的操作模式; 以及主控制部，其基于所述照射条件，基于所选择的操作模式和照射装置对每个切片进行加速器的控制。

公开(公告)号：US08586942B2

公开(公告)日：2013-11-19

申请号：US13639998

申请日：2012-01-20

Applicant: Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Yukiko Yamada

Inventor： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Yukiko Yamada

IPC: H01J3/10

CPC classification number: A61N5/1048 ,  A61N5/1043 ,  A61N5/1071 ,  A61N2005/1074 ,  A61N2005/1087 ,  G01T1/29 ,  G21K5/00 ,  G21K5/02

Abstract: A charged particle beam position monitor is provided with a plurality of position monitors and a beam data processing device that performs calculation processing of the state of a charged particle beam, based on a plurality of signals outputted from the position monitors. The beam data processing device includes a plurality of channel data conversion units that perform AD conversion processing of the plurality of signals outputted from the position monitors; a position size processing unit, for each of the position monitors, that calculates the beam position of the beam, based on voltage information obtained through the AD conversion processing; and an integrated control unit that controls the plurality of channel data conversion units in such a way that while the beam is irradiated onto an irradiation subject, AD conversion processing of the signals is performed at different timings for the respective position monitors.

Abstract translation: 带电粒子束位置监视器具有多个位置监视器和根据从位置监视器输出的多个信号执行带电粒子束的状态的计算处理的波束数据处理装置。 所述波束数据处理装置包括对从所述位置监视器输出的所述多个信号进行AD转换处理的多个信道数据变换部; 基于通过AD转换处理获得的电压信息，对位置监视器中的每一个计算光束位置的位置尺寸处理单元; 以及集成控制单元，其以这样的方式控制多个通道数据转换单元，即当将光束照射到照射对象时，对于各个位置监视器，在不同的定时执行信号的AD转换处理。

公开(公告)号：US20130274538A1

公开(公告)日：2013-10-17

申请号：US13977058

申请日：2011-03-07

Applicant: Yukiko Yamada ,  Hisashi Harada ,  Takaaki Iwata ,  Toshihiro Otani ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

Inventor： Yukiko Yamada ,  Hisashi Harada ,  Takaaki Iwata ,  Toshihiro Otani ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC: A61N5/10

CPC classification number: A61N5/1048 ,  A61N5/1043 ,  A61N5/1075 ,  A61N2005/1087 ,  G21K1/093

Abstract: The particle beam irradiation apparatus comprises: a position monitor that detects a passing position of a charged particle beam; and an irradiation control apparatus that calculates a distance from a predetermined reference point to the position monitor, calculates a beam irradiation position on an irradiation subject, and controls irradiation of the beam; wherein the irradiation control apparatus includes a position calculation apparatus that calculates the beam irradiation position, based on a beam position detected by the position monitor, a scanning starting point distance information on a distance from a irradiation plane of the irradiation subject to a scanning starting point, of the beam, in a scanning electromagnet, and a position monitor distance information on a distance, from the irradiation plane to the position monitor, that is calculated based on the calculated distance.

Abstract translation: 粒子束照射装置包括：位置监视器，其检测带电粒子束的通过位置; 以及照射控制装置，其计算从预定基准点到所述位置监视器的距离，计算照射对象的光束照射位置，并控制所述光束的照射; 其特征在于，所述照射控制装置包括：位置计算装置，其基于由所述位置监视器检测到的光束位置计算所述光束照射位置;从所述照射对象的照射面到扫描开始点的距离的扫描开始点距离信息 ，扫描电磁体中的距离信息，以及从照射平面到位置监视器的基于计算出的距离计算的位置监视距离信息。