Peritoneal dialysis method
    5.
    发明授权
    Peritoneal dialysis method 失效
    腹膜透析法

    公开(公告)号:US4976683A

    公开(公告)日:1990-12-11

    申请号:US220779

    申请日:1988-07-18

    IPC分类号: A61M1/28

    CPC分类号: A61M1/28 A61M1/287

    摘要: This invention relates to an improved method for conducting peritoneal dialysis with a decreased total volume of dialysis fluid used and increased efficacy parameters such as ultrafiltration rate, urea clearance rate and dialysate volume as compared to conventional techniques. In the method of this invention, a fluid communication through the peritoneal membrane into the peritoneal cavity of a patient in need of peritoneal dialysis treatment is established. An initial volume of an aqueous peritoneal dialysis composition containing an osmotic agent is instilled into the peritoneal cavity through the fluid communication. The dialysis composition contains an amount of dissolved osmotic agent (i) that is insufficient to adequately dialyze the patient during a predetermined time period of dialysis treatment, but (ii) that is present at an osmolarity that is greater than the osmolarity of the body fluids in contact with the membrane, such that an osmolarity gradient is created across the membrane between the composition and the body fluids. A flux of water and solute enters the composition from the body fluids by means of that gradient.A further amount of dissolved osmotic agent is released into the instilled dialysis composition to form a modified dialysis composition. That further osmotic agent is released in an amount sufficient to maintain a substantially constant osmolarity gradient between the modified dialysis composition and the body fluids such that the water and solute flux continues to enter into the modified dialysis composition during the predetermined dialysis time period. The modified dialysis composition is substantially removed from the peritoneal cavity at the end of the treatment time period.

    摘要翻译: 本发明涉及一种改进的腹膜透析方法,与常规技术相比,使用的透析液的总体积减少,并且提高了功效参数,例如超滤速率,尿素清除率和透析液体积。 在本发明的方法中,建立了通过腹膜进入需要腹膜透析治疗的患者的腹腔的液体连通。 通过流体连通将含有渗透剂的含水性腹膜透析组合物的初始体积滴入腹膜腔。 透析组合物含有一定量的溶解渗透剂(i),其不足以在透析治疗的预定时间段期间充分透析患者,但(ii)存在的渗透压大于体液的渗透压 与膜接触,使得跨组合物和体液之间的膜产生渗透压梯度。 水和溶质的通量通过该梯度从体液进入组合物。 将另外量的溶解的渗透剂释放到滴入浓缩组合物中以形成改性透析组合物。 该释放出的进一步的渗透剂量足以在修饰的透析组合物和体液之间保持基本恒定的渗透压梯度,使得水和溶质通量在预定的透析时间期间继续进入修饰的透析组合物。 在治疗时间段结束时,改良的透析组合物基本上从腹膜腔中除去。