公开(公告)号：US20230407290A1

公开(公告)日：2023-12-21

申请号：US18179311

申请日：2023-03-06

Applicant: Twist Bioscience Corporation

Inventor： Siyuan CHEN ,  Xuan Yu Elian LEE ,  David LIN ,  Daniel J. RAMIREZ ,  Tavneet GILL ,  Patrick CHERRY ,  Esteban TORO

IPC: C12N15/10

CPC classification number: C12N15/1031

Abstract: Provided herein are methods, systems, and compositions for efficient nucleic acid assembly with improved representation and distribution. Provided herein are methods, systems, and compositions for efficient nucleic acid assembly of nucleic acids encoding genes for use in various downstream processes.

公开(公告)号：US20220356463A1

公开(公告)日：2022-11-10

申请号：US17715890

申请日：2022-04-07

Applicant: Twist Bioscience Corporation

Inventor： Jinfeng SHEN ,  Michael BOCEK ,  David LIN ,  Alonzo LEE ,  Patrick CHERRY ,  Siyuan CHEN ,  Esteban TORO ,  Leslie QUINTANILLA-ZARINAN

IPC: C12N15/10

Abstract: Provided herein are compositions and methods for identifying genomic variants. Further provided herein are standards useful for determining the analytical sensitivity and/or accuracy of instruments configured to measure nucleic acid variant frequencies.

公开(公告)号：US20220325276A2

公开(公告)日：2022-10-13

申请号：US15156134

申请日：2016-05-16

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE ,  Cheng-Hsien WU ,  Esteban TORO

IPC: C12N15/10

Abstract: Methods and devices for cell-free sorting and cloning of nucleic acid libraries are provided herein.

公开(公告)号：US20220106586A1

公开(公告)日：2022-04-07

申请号：US17410962

申请日：2021-08-24

Applicant: Twist Bioscience Corporation

Inventor： Rebecca NUGENT ,  Siyuan CHEN ,  Leonardo ARBIZA ,  Esteban TORO ,  Michael BOCEK

IPC: C12N15/10 ,  C12Q1/6874 ,  C12Q1/6855 ,  C12Q1/6811 ,  C12Q1/70

Abstract: Provided herein are compositions and methods for next generation sequencing using universal polynucleotide adapters. Further provided are universal adapters which provide for a large number of samples to be sequenced in parallel. Further provided are methods for high-throughput testing of samples for disease testing.

公开(公告)号：US20200299684A1

公开(公告)日：2020-09-24

申请号：US16759282

申请日：2018-10-26

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Esteban TORO ,  James DIGGANS ,  Siyuan CHEN ,  Anthony COX ,  Arthur VIGIL ,  Kieran HERVOLD

IPC: C12N15/10 ,  G16B30/20 ,  G16B30/10

Abstract: The present disclosure describes software tools for predicting the feasibility of synthesizing and assembling polynucleotides. Polynucleotide scoring tools describe herein provide automated methods for predicting efficient strategies and reaction conditions for synthesizing and assembling polynucleotides.