公开(公告)号：US20230201181A1

公开(公告)日：2023-06-29

申请号：US18115436

申请日：2023-02-28

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Robert S. Chao ,  Miroslav Rapta

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

CPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

公开(公告)号：US20220087995A1

公开(公告)日：2022-03-24

申请号：US17248692

申请日：2021-02-03

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Stangeland

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US10441579B2

公开(公告)日：2019-10-15

申请号：US16239265

申请日：2019-01-03

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Stangeland

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US20180050024A1

公开(公告)日：2018-02-22

申请号：US15591419

申请日：2017-05-10

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Stangeland ,  Sheila Zipfel ,  Daniel D. Long

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

CPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US11596624B2

公开(公告)日：2023-03-07

申请号：US17248737

申请日：2021-02-05

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Robert S. Chao ,  Miroslav Rapta

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

公开(公告)号：US10946007B2

公开(公告)日：2021-03-16

申请号：US16903579

申请日：2020-06-17

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Stangeland

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US10946006B2

公开(公告)日：2021-03-16

申请号：US16744551

申请日：2020-01-16

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Robert S. Chao ,  Miroslav Rapta

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

公开(公告)号：US10576073B2

公开(公告)日：2020-03-03

申请号：US16244956

申请日：2019-01-10

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Robert S. Chao ,  Miroslav Rapta

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

公开(公告)号：US20240316024A1

公开(公告)日：2024-09-26

申请号：US18443907

申请日：2024-02-16

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Strangeland ,  Sheila Zipfel ,  Daniel D. Long

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

CPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I:




where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US20200316048A1

公开(公告)日：2020-10-08

申请号：US16903579

申请日：2020-06-17

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Lori Jean Patterson ,  Eric L. Stangeland

IPC分类号： A61K31/4465 ,  C07D211/22 ,  C07D211/32

摘要： The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.