公开(公告)号：US20240052006A1

公开(公告)日：2024-02-15

申请号：US18246512

申请日：2021-09-24

申请人： THE UNIVERSITY OF CHICAGO

发明人： Jeffrey A HUBBELL ,  Eiji YUBA ,  Elyse WATKINS ,  Jun ISHIHARA ,  Ako ISHIHARA ,  Erica BUDINA ,  Abigail LAUTERBACH

IPC分类号： C07K14/54 ,  A61P37/02 ,  C12N15/63

CPC分类号： C07K14/54 ,  A61P37/02 ,  C12N15/63 ,  C07K2319/31

摘要： Aspects of the present disclosure provide methods and compositions for treatment of autoimmune disorders including, for example, multiple sclerosis and rheumatoid arthritis. Also disclosed are methods for promoting wound healing. Certain aspects are directed to antiinflammatory cytokines operatively linked to an albumin protein. Further aspects relate to methods for delivering an anti-inflammatory cytokine to a lymph node.

公开(公告)号：US20240207213A1

公开(公告)日：2024-06-27

申请号：US18556006

申请日：2022-04-18

申请人： THE UNIVERSITY OF CHICAGO

发明人： Jeffrey HUBBELL ,  Shijie CAO ,  Michal RACZY ,  Elyse WATKINS ,  Erica BUDINA

IPC分类号： A61K31/221 ,  A61K9/00 ,  A61P37/00

CPC分类号： A61K31/221 ,  A61K9/0053 ,  A61P37/00

摘要： Described herein are novel methods of treating disorders using oral, systemically bioavailable forms of butyrate. Aspects of the disclosure relate to a method for treating a disorder in a subject comprising administering the oral, systemically bioavailable composition to the subject, wherein the disorder is selected from inflammatory bowel disease (IBD), multiple sclerosis (MS), a neuroinflammatory condition, food allergies, rheumatoid arthritis (RA), asthma, celiac disease, non-alcoholic steatohepatitis (NASH), diabetes, Alzheimer's disease (AD), inflammaging, beta-hemoglobinopathies, vascular inflammatory conditions, atopic dermatitis and psoriasis, pulmonary fibrosis, and systemic sclerosis.